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Product Description
Trophoblast glycoprotein, also known as TPBG or 5T4, is a human cell surface protein encoded by a TPBG gene and an antagonist of the of Wnt/β-catenin signaling pathway. TPBG/5T4 is rarely expressed in normal adult tissues, but is present at high levels in placenta and in most common tumors, typically more than 80% of carcinomas of the kidney, breast, colon, prostate, and ovary. Due to its selective expression, it is often used as a prognostic aid in cancer cases. Recently, it has been shown that TPBG inhibits Wnt/β-catenin signaling, a signaling system central to many developmental and pathological processes and therefore serves as a therapeutic target of several anticancer agents currently in clinical development.
Biovision | P1553 | Human CellExp™ TPBG, Human Recombinant DataSheet
Biomolecule/Target :
Synonyms: Trophoblast glycoprotein, 5T4 oncofetal antigen, 5T4 oncofetal trophoblast glycoprotein, 5T4 oncotrophoblast glycoprotein, M6P1, Wnt-activated inhibitory factor 1, WAIF1,TPBG
Alternates names: Trophoblast glycoprotein, 5T4 oncofetal antigen, 5T4 oncofetal trophoblast glycoprotein, 5T4 oncotrophoblast glycoprotein, M6P1, Wnt-activated inhibitory factor 1, WAIF1,TPBG
Taglines: Antagonist of the of Wnt/β-catenin signaling pathway
NCBI Gene ID #: 7162
NCBI Gene Symbol: TPBG
Gene Source: Human
Accession #: Q13641
Recombinant: TRUE
Source: HEK 293 cells
Purity by SDS-PAGE: >95%
Assay: SDS - PAGE
Purity:
Assay #2:
Endotoxin Level:
Activity (Specifications/test method):
Biological activity:
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Binding Capacity:
Unit Definition:
Molecular Weight: 36.5 kDa (6xHis tag fused to C-terminus with GS linker)
Concentration:
Appearance: Lyophilized powder
Physical form description: Lyophilized
Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in sterile PBS (pH 7.4). Do not vortex.
Amino acid sequence: Ser 32 – Ser 355
Handling: Centrifuge the vial prior to opening.
Usage: For Research Use Only! Not to be used in humans
