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Product Description
Fibrinogen is a glycoprotein complex composed of three different polypeptides (α, β, γ) that is cleaved by thrombin to form an insoluble fibrin matrix that acts as a plasma clotting factor. Cleavage products of fibrinogen and fibrin regulate cell adhesion and activate chemotaxis. Chronic inflammation can induce protein arginine deiminases (such as PAD2 and PAD4) to citrullinate fibrinogen, which has been associated with auto-antibodies in rheumatoid arthritis.
Biovision | P1718 | Human Fibrinogen (PAD2 Citrullinated) DataSheet
Biomolecule/Target :
Synonyms: Fib2; FGA; HEL-S-78p; FGB; FGG
Alternates names:
Taglines: A critical factor in blood clotting, inflammation, and rheumatoid arthritis
NCBI Gene ID #: α - 2243; β - 2244; γ - 2266
NCBI Gene Symbol:
Gene Source: Human
Accession #: α - P02671; β - P02675; γ - P02679
Recombinant: False
Source: Human plasma
Purity by SDS-PAGE: ≥ 95% by SDS-PAGE
Assay:
Purity:
Assay #2:
Endotoxin Level:
Activity (Specifications/test method):
Biological activity:
Results:
Binding Capacity:
Unit Definition:
Molecular Weight: α - 2 isoforms at 95 kDa and 69.8 kDa; β - 55.9 kDa; γ - 51.5 kDa
Concentration:
Appearance: Liquid protein
Physical form description:
Reconstitution Instructions:
Amino acid sequence: Purified from human plasma that tested negative for HBsAg and for antibodies to HIV and HCV; citrullinated with human recombinant PAD2
Handling: Centrifuge the vial prior to opening.
Usage: For Research Use Only! Not to be used in humans
