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Product Description
Hec1 is a component of the kinetochore outer layer, which is required for chromosome segregation and spindle checkpoint activity. It is required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. It is overexpressed in a variety of human cancers and maybe used for the prognosis of primary breast cancer.
Biovision | P1671 | Human Hec1 DataSheet
Biomolecule/Target :
Synonyms: Kinetochore protein NDC80 homolog; Highly expressed in cancer protein; Kinetochore protein Hec1; HsHec1; Kinetochore-associated protein 2; Retinoblastoma-associated protein HEC
Alternates names: Kinetochore protein NDC80 homolog; Highly expressed in cancer protein; Kinetochore protein Hec1; HsHec1; Kinetochore-associated protein 2; Retinoblastoma-associated protein HEC
Taglines: A component of the kinetochore outer layer
NCBI Gene ID #:
NCBI Gene Symbol:
Gene Source: Human
Accession #: O14777
Recombinant: 1
Source: E.coli
Purity by SDS-PAGE: ≥ 90% by SDS-PAGE
Assay:
Purity:
Assay #2:
Endotoxin Level:
Activity (Specifications/test method):
Biological activity:
Results:
Binding Capacity:
Unit Definition:
Molecular Weight: 41.01 kDa
Concentration:
Appearance: Lyophilized protein
Physical form description:
Reconstitution Instructions: Reconstitute in sterile water to a concentration of 1 mg/ml.
Amino acid sequence: The target protein is expressed with the sequence Pro290-Glu642 of human Hec1 with a His tag at the N-terminus.
Handling: Centrifuge the vial prior to opening.
Usage: For Research Use Only! Not to be used in humans
