Biovision | Human Recombinant Proteins

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Biovision | TARC, human recombinant | 4333

Human TARC is a recently discovered protein belonging to the -chemokine (C-C) family of cytokines. It has been shown that TARC is chemotactic towards T-cells but ineffective on monocytes. The recombinant human TARC is an 8.0 kDa protein containing 71...

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Biovision | TAFA-2, human recombinant | 7213

TAFA proteins are a newly discovered family of proteins, which are distantly related to MIP-1alpha, a member of the CC-chemokine family. TAFA mRNAs are highly expressed in specific brain regions. The biological function of TAFA-2 is still unknown...

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Biovision | TACI, human recombinant | 7212

TACI, a member of the TNF Receptor superfamily, is expressed in the small intestine, spleen, thymus, peripheral blood leukocytes, activated T cells, and resting B cells. TACI binds to both APRIL and BAFF and can stimulate the activation of transcription...

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Biovision | TACE (TNF- converting enzyme), human recombinant | 7607

TACE (TNF-alpha converting enzyme, ADAM17) is a membrane-bound Metalloprotease from the ADAM (a disintegrin and Metalloprotease) family of proteins. It cleaves 26kDa type II membrane-bound precursor of TNF-a into 17 kDa mature form which is secreted...

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Biovision | Survivin, human recombinant | 4160

Survivin, a member of the inhibitor of apoptosis (IAP) family, is also called baculoviral inhibitor of apoptosis repeat-containing 5 or BIRC5 and in humans is encoded by the BIRC5 gene. The survivin protein functions to inhibit caspase activation,...

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Biovision | Superoxide Dismutase (SOD), human recombinant | 4802

Superoxide Dismutase (SOD) is an oxidoreductase that catalyzes the reaction between superoxide anions and hydrogen to yield molecular oxygen and hydrogen peroxide. The enzyme protects the cell against dangerous levels of superoxide. Recombinant Human...

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Biovision | SUMO3, human recombinant | 4943

SUMO modification has been implicated in functions such as nuclear transport, chromosome segregation and transcriptional regulation. SUMO functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational...

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Biovision | SUMO2, human recombinant | 4942

SUMO modification has been implicated in functions such as nuclear transport, chromosome segregation and transcriptional regulation. SUMO1 functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational...

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Biovision | SUMO1, human recombinant | 4941

SUMO modification has been implicated in functions such as nuclear transport, chromosome segregation and transcriptional regulation. SUMO1 functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational...

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Biovision | sTRAIL Receptor-1/DR4, human recombinant | 7206

TRAIL Receptor-1/DR4 and TRAIL Receptor-2/DR5 belong to the TNFR superfamily of transmembrane proteins and contain a cytoplasmic death domain, which can activate the cells apoptotic machinery. These receptors are activated by binding to either...

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Biovision | sTNF-RI, human recombinant | 4348

Tumor Necrosis Factor receptor type I (TNF-RI) is also referred as p60. The p60 form of the receptor is primarily expressed on epithelial cells. Recombinant Human soluble TNF receptor Type I (sTNF-RI) is a 18.3 kDa protein containing 162 amino acid...

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Biovision | STAT1 (His-tagged), human recombinant | 7889

Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors,...

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Biovision | sRANK Receptor, human recombinant | 7193

RANKL and RANK are members of the TNF superfamily of ligands and receptors that play an important role in the regulation of specific immunity and bone turnover. RANK (receptor) was originally identified as a dendritic-cell-membrane protein, which by...

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Biovision | sRANK Ligand, human recombinant | 4318

Human RANK (receptor activator of NF-kB) is a member of the TNFR family, identified as a dentritic cell membrane protein. Human soluble RANK Ligand is a soluble 20.0 kDa polypeptide, comprising the TNF homologous region of RANKL (176 amino acid residues)...

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Biovision | SPARC/Osteonectin, human recombinant | 7204

SPARC/Osteonectin is a secreted, evolutionarily conserved collagen-binding glycoprotein that is involved in a variety of cellular activities. It is highly expressed in tissues undergoing morphogenesis, remodeling and wound repair. SPARC/Osteonectin and...

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Biovision | Sox2-TAT, human recombinant | 7203

Sox2, also known as sex determining region Y (SRY)-box 2, belongs to a diverse family of structurally-related transcription factors whose primary structure contains a 79-residue DNA-binding domain, called high mobility group (HMG) box. It plays an...

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Biovision | Sox2, human recombinant | 7202

Sox2, also known as sex determining region Y (SRY)-box 2, belongs to a diverse family of structurally-related transcription factors whose primary structure contains a 79-residue DNA-binding domain, called high mobility group (HMG) box. It plays an...

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Biovision | SMN Tudor Domain (73-173 aa) GST-tagged), Human recombinant | 7676

Tudor domains are small protein structural motifs of ~50 amino acids related to the Royal family of methyl readers, which also includes chromo, MBT, PWWP, and Agenet-like domains. Tudor domains occur either alone, in tandem, or with other domains and...

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Biovision | Sirtuin 2, human recombinant | 7632

Human sirtuins function as intracellular regulatory proteins. Sirtuin 2 is a member of the class III histone deacetylases (HDACs) and has been implicated in many cellular processes that include histone deacetylation, gene silencing, chromosomal...

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Biovision | SIRT7 (2-400 aa) (His-tagged), Human recombinant | 7675

The sirtuins represent a distinct class of trichostatin A-insensitive lysyl-deacetylases (class III HDACs) and have been shown to catalyze a reaction that couples lysine deacetylation to the formation of nicotinamide and O-acetyl-ADP-ribose from NAD+ and...

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Biovision | SIRT5 (GST-tagged), Human recombinant | 7674

The sirtuins represent a distinct class of trichostatin A-insensitive lysyl-deacetylases (class III HDACs) and have been shown to catalyze a reaction that couples lysine deacetylation to the formation of nicotinamide and O-acetyl-ADP-ribose from NAD+ and...

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Biovision | SIRT4 (GST-tagged), Human recombinant | 7673

There are seven human sirtuins, also known as class III HDACs, which have been designated SIRT1 to SIRT7. Each is involved in various post-translational modifications by utilizing NAD dependent deacetylase and APD-ribosyltransferase activities. SIRT4 is...

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Biovision | SIRT1 (193-747 aa) (GST-tagged), Human recombinant | 7264

The sirtuins represent a distinct class of trichostatin A-insensitive lysyl-deacetylases (class III HDACs) and have been shown to catalyze a reaction that couples lysine deacetylation to the formation of nicotinamide and O-acetyl-ADP-ribose from NAD+ and...

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Biovision | sFas Receptor, human recombinant | 7141

Fas and Fas Ligand (FasL) belong to the TNF superfamily and are type I and type II transmembrane proteins, respectively. Binding of FasL to Fas triggers apoptosis in Fas-bearing cells. The mechanism of apoptosis involves recruitment of pro-caspase 8...

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Biovision | sFas Ligand, human recombinant | 7140

Fas Ligand (FasL) is a member of the TNF superfamily that is expressed on the cell surface of activated T cells. Binding of FasL to Fas Receptor triggers apoptosis in Fas-bearing cells. FasL has the ability to kill T cells and activated B cells which...

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Biovision | Serpin E1/PAI-1, human recombinant | 4731

Serpins are a group of proteins with similar structures that were first identified as a set of proteins able to inhibit proteases. They are the largest and most diverse family of serine protease inhibitors which are involved in a number of fundamental...

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Biovision | Semaphorin 3A, human recombinant | 7201

Semaphorins are a large group of structurally related secreted, GPI-anchored and transmembrane cell signaling molecules. There are 8 major classifications (1-7) of Semaphorins characterized by the existence of a conserved 500 amino acid SEMA domain at...

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Biovision | SDF-1beta (CXCL12), human recombinant | 4390

Stromal cell-derived factor-1 is a stromal derived CXC chemokine. It signals through CXCR4 receptor. Recombinant Human SDF-1 is an 8.5 kDa protein containing 72 amino acid residues.Biovision | 4390 | SDF-1beta CXCL12 human recombinant...

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Biovision | SDF-1alpha (CXCL12), human recombinant | 4387

Human Stromal Cell-Derived Factor-1 (SDF-1) is a recently discovered protein belonging to the -chemokine (C-X-C) family of cytokines. Human SDF-1 is an 8.0 kDa protein containing 68 amino acids residues with N-terminus His-tagBiovision | 4387 |...

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Biovision | SCGF-, human recombinant | 7198

SCGF alpha and beta are hematopoietic growth factor that exerts their activity at early stages of hematopoiesis. The SCGFs are non-glycosylated species-specific cytokines that can support growth of primitive hematopoietic cells, and in combination with...

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Biovision | SCF, human recombinant | 4327

Stem Cell Factor (SCF) is a hematopoietic growth factor that exerts its activity at the early stages of hematopoiesis. SCF stimulates the proliferation of myeloid, erythroid, and lymphoid progenitors in bone marrow cultures. Human SCF is an 18.4 kDa...

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Biovision | sCD34, Human Recombinant | P1286

CD34 is a highly glycosylated type I membrane protein that is selectively expressed on hematopoietic stem cells and vascular endothelium. It has been widely used as a molecular marker for the identification, isolation, and manipulation of hemopoietic...

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Biovision | sCD30 Ligand, Human Recombinant | P1285

CD30 ligand (CD30L) is a type-II membrane-associated glycoprotein protein belonging to the TNF superfamily and is expressed primarily on certain B cells, T cells, and monocytes. CD30L binds specifically to CD30 (receptor), which is expressed on...

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Biovision | sCD27 Ligand, Human Recombinant | 7125

CD27 Ligand, a type II transmembrane protein, is a member of the TNF superfamily. It is expressed on activated T and B lymphocytes as well as NK cells. CD27L and its receptor (CD27) regulate the immune response by promoting T-cell expansion and...

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Biovision | sCD23, Human Recombinant | 7124

CD23, the low affinity receptor for IgE, belongs to the C-type lectin structural family and plays a role in the regulation of IgE synthesis and IgE mediated activities. It is found both as a transmembrane receptor protein and in a soluble form, which is...

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Biovision | sCD22, Human Recombinant | 7123

CD22 is a B-lineage restricted 135 kDa glycoprotein whose cell surface expression is limited to resting and activated B lymphocytes. The physiological role of CD22 is still unknown. Targeted disruption of CD22 in mice results in a reduced level of...

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Biovision | S100B, human recombinant | P1035

S100B also known as protein S100-B. S100B is a protein of the S100 protein family. S100 proteins comprise a multigene family of EF-hand calcium binding proteins that engage in multiple functions in response to cellular stress. S100B protein has been...

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Biovision | R-Spondin-3, human recombinant | 7191

The R-Spondin (Rspo) proteins belong to the Rspo family of Wnt modulators. Currently, the family consists of four structurally related secreted ligands (Rspo 1-4), all containing furin-like and thrombospondin structural domains. The Rspo proteins can...

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Biovision | R-Spondin-2, human recombinant | 7190

The R-Spondin (Rspo) proteins belong to the Rspo family of Wnt modulators. Currently, the family consists of four structurally related secreted ligands (Rspo 1-4), all containing furin-like and thrombospondin structural domains. The Rspo proteins can...

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Biovision | R-Spondin-1, human recombinant | 7189

R-Spondin-1 (Rspo-1) belongs to the (Rspo) family of Wnt modulators. Currently, the family consists of four structurally related secreted ligands (Rspo 1-4), all containing furin-like and thrombospondin structural domains. Rspo-1 is expressed in certain...

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Biovision | Resistin, human recombinant | 4559

Human Resistin is a new member to the family of adipocyte secreted proteins. The biological functions of Resistin as well as its molecular target is larGely unknown. Whether it promotes or antagonizes insulin action is still unclear. Recombinant Resistin...

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Biovision | RELM-beta, human recombinant | 4654

Human RELM (Resistin-like molecule /FIZZ2) is a new member to the family of adipocyte secreted proteins called adipocytokines. This family includes the RELM , RELM and Resistin molecules. Interestingly, RELM and Resistin share similar characteristics...

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Biovision | Relaxin-3, human recombinant | 7195

Relaxin-3 (H3 relaxin, Insulin-like peptide-7, INSL7) is a secreted protein structurally related to insulin, which is expressed primarily in the brain and central nervous system. Relaxin-3 has been identified as the ligand for the GPCR135 receptor,...

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Biovision | Relaxin-2, human recombinant | 7194

Relaxin-2 is a peptide hormone structurally related to insulin, which is expressed in the placenta, decidua, prostate, and in the ovary during pregnancy. Of the three known relaxin genes, Relaxin-2 is the only relaxin known to circulate in the blood...

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Biovision | RBP4, human recombinant | 4940

Retinol binding protein 4(RBP4) belongs to the lipocalin family and is the specific carrier for retinol (vitamin A alcohol) in the blood. This protein was found to be expressed and secreted by adipose tissue, and was strongly associated with insulin...

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Biovision | RASSF1A, human recombinant | P1114

RASSF1A is similar to the RAS effector proteins. Loss or altered expression of this gene has been associated with the pathogenesis of a variety of cancers, which suggests the tumor suppressor function of this gene. The inactivation of this gene was found...

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Biovision | RANTES, human recombinant | 4321

RANTES is a CC-chemokine that can signal through the CCR1, CCR3, CCR5 and US28 (cytomegalovirus receptor) receptors. It is a chemoattractant towards monocytes, memory T cells (CD4+/CD45RO), basophils, and eosinophils. RANTES also has the capability to...

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Biovision | RAGE, human recombinant | 4271

Advanced glycosylation end product-specific receptor, also known as receptor for advanced glycosylation end products, AGER and RAGE, belongs to the immunoglobulin superfamily of cell surface molecules. It lies within the major histocompatibility complex...

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Biovision | R³ IGF-1, human recombinant | 4216

IGF-I (insulin-like Growth Factor-I) is a polypeptide growth factor that stimulates the proliferation of a wide range of cell types including muscle, bone, and cartilage tissue. BioVisions recombinant human IGF-I is a N-terminus modified IGF-I with a...

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Biovision | PTHrP, human recombinant | 4651

Parathyroid Hormone-like related Protein (PTHrP) is a member of the Parathyroid hormone family that is expressed in the mammary gland. It is known as a potent inhibitor of chondrocyte maturation. PTHrP is expressed by periarticular perichondrial cells...

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Biovision | PTH, human recombinant | 4650

Parathyroid Hormone (PTH) is the most important endocrine regulator of calcium and phosphorus concentration in extraCellular fluid. This hormone is secreted from cells of the parathyroid glands and targets cells in bone and kidney. Like other protein...

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Biovision | Pro-Urokinase, human recombinant | 7695

Urokinase or Urokinase-type plasminogen activator (uPA) is a serine protease (EC 3.4.21.73). It is secreted as a single-chain zymogen, pro-Urokinase, possessing little or no intrinsic enzymatic activity. The single chain zymogen is converted into the...

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