Euro
USD
British Pound
NULL
Product Description
ICAM-3/CD50, also known as CD50 (Cluster of Differentiation 50), is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulinlike C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is constitutively and abundantly expressed by all leukocytes and maybe the most important ligand for LFA-1 in the initiation of the immune response. It functions not only as an adhesion molecule, but also as a potent signaling molecule. Recombinant human ICAM-3/CD50, fused hIgG-His-tag at C-terminus, was expressed in the insect cell and purified by using conventional chromatography techniques.
Biovision | P1564 | ICAM-3, Human Recombinant DataSheet
Biomolecule/Target :
Synonyms: ICAM3, Intercellular adhesion molecule 3, ICAM-3, CD50, CDW50, ICAM-R, intercellular adhesion molecule 3 isoform 1
Alternates names: ICAM3, Intercellular adhesion molecule 3, ICAM-3, CD50, CDW50, ICAM-R, intercellular adhesion molecule 3 isoform 1
Taglines: Contributes to apoptotic neutrophil phagocytosis by macrophages
NCBI Gene ID #: 3385
NCBI Gene Symbol: ICAM3
Gene Source: Human
Accession #: P32942
Recombinant: TRUE
Source: Baculovirus
Purity by SDS-PAGE: >95%
Assay: SDS - PAGE
Purity:
Assay #2:
Endotoxin Level: < 1 EU per 1ug of protein (determined by LAL method)
Activity (Specifications/test method):
Biological activity: Measured by the ability of the immobilized protein to support the adhesion of HL-60 human promyelocytic cells. When cells are added to Human ICAM-3/CD50 coated plates, the ED50 range ≤4ug/ml.
Results:
Binding Capacity:
Unit Definition:
Molecular Weight: 76.7 kDa (hIgG-His-tag at C-terminus)
Concentration:
Appearance: Liquid
Physical form description: Liquid
Reconstitution Instructions:
Amino acid sequence: aa 30-485
Handling: Centrifuge the vial prior to opening.
Usage: For Research Use Only! Not to be used in humans
