Euro
USD
British Pound
NULL
Product Description
SARS-CoV is an enveloped, single and positive-stranded RNA virus. Cell entry of severe acute respiratory syndrome coronavirus (SARS-CoV) is mediated by the viral spike (S) protein. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. For viral entry, the surface unit (S1) of SARS S binds to the cellular receptor angiotensinconverting enzyme 2 (ACE2) and the transmembrane unit (S2) then fuses the viral membrane with a host cell membrane. The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity, during infection with SARS-CoV. Because the S protein of SARS-CoV is involved in receptor recognition, as well as virus attachment and entry, it represents one of the most important targets for the development of SARS vaccines and therapeutics.
Biovision | P1734 | SARS-CoV-2 Spike Protein Receptor Binding Domain, Recombinant DataSheet
Biomolecule/Target :
Synonyms: Spike glycoprotein RBD; S1 RBD
Alternates names: Spike glycoprotein RBD; S1 RBD
Taglines: A key protein in allowing viral entry into host cells
NCBI Gene ID #: 43740568
NCBI Gene Symbol:
Gene Source: SARS-CoV-2
Accession #: P0DTC2
Recombinant: True
Source: Mammalian Cells
Purity by SDS-PAGE: > 90% as determined by SDS-PAGE
Assay:
Purity:
Assay #2:
Endotoxin Level:
Activity (Specifications/test method):
Biological activity:
Results:
Binding Capacity:
Unit Definition:
Molecular Weight: 53 kDa
Concentration:
Appearance: Lyophilized protein
Physical form description: Lyophilized powder
Reconstitution Instructions:
Amino acid sequence: Arg 319 to Phe 541 with C-terminal Fc Tag
Handling: Centrifuge the vial prior to opening.
Usage: For Research Use Only! Not to be used in humans
![Recombinant SARS-CoV-2 Spike Protein Receptor Binding Domain [His]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/500x659/products/452652/655785/images__81618.1648113406__34346.1648114922.png?c=2 "Recombinant SARS-CoV-2 Spike Protein Receptor Binding Domain [His]")
![Recombinant SARS-CoV-2 Spike Protein Receptor Binding Domain [mFc]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/500x659/products/452381/655514/images__81618.1648113406__91020.1648114889.png?c=2 "Recombinant SARS-CoV-2 Spike Protein Receptor Binding Domain [mFc]")
![Recombinant SARS-CoV-2 Spike Protein Receptor Binding Domain [hFc]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/500x659/products/452380/655513/images__81618.1648113406__65786.1648114889.png?c=2 "Recombinant SARS-CoV-2 Spike Protein Receptor Binding Domain [hFc]")
