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Biovision | CEP-33779 | B2473

CEP-33779 is a potent and orally available inhibitor of JAK2 (IC₅₀ = 1.3 nM). It displays 65-fold selectivity for JAK2 over JAK3. CEP-33779 induces regression of established colorectal tumors,...

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Biovision | Alvimopan | B2472

Alvimopan is a peripherally acting μ-opioid receptor antagonist (Ki = 0.47 nM) that is selective over the κ- and δ-opioid receptors (Ki's = 100 nM and 12 nM, respectively). It is used to avoid...

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Biovision | dBET6 | B2471

dBET6 is a highly potent, selective and cell-permeable degrader of BET based on PROTAC, with an IC₅₀ of 14 nM. dBET6 prompts a collapse of global elongation that phenocopies CDK9 inhibition. Displays...

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Biovision | PF-04965842 | B2470

PF-04965842 (Abrocitinib) is a potent, selective, orally bioavailable JAK1 inhibitor (IC₅₀ = 29 nM). It displays excellent selectivity for JAK1 versus other JAK family enzymes.PF-04965842...

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Biovision | Reparixin | B2469

Reparixin is a non-competitive allosteric inhibitor of the chemokine receptors CXCR1 and CXCR2 activation with IC₅₀s of 1 and 100 nM, respectively. Blocks a range of activities including leukocyte...

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Biovision | PF-3084014 | B2468

PF-3084014 (Nirogacestat) is a potent and selective gamma-secretase inhibitor (IC₅₀ of 6.2 nM). Reduces Aβ in brain, CSF and plasma in mice and guinea pigs.PF-3084014 (Nirogacestat) is a potent and...

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Biovision | PF-04449913 | B2467

PF-04449913 is a potent and orally bioavailable smoothened (SMO) inhibitor. PF-04449913 binds to human SMO with an IC₅₀ of 4 nM. It has been shown to attenuate leukemia stem cell self-renewal and...

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Biovision | Sulfatinib | B2466

Sulfatinib is a potent, orally bioavailable and highly selective tyrosine kinase inhibitor against VEGFR1/2/3, FGFR1 and CSF1R with IC₅₀s of in a range of 1 to 24 nM.Sulfatinib is a potent, orally...

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Biovision | Amrinone | B2465

Amrinone is a potent phosphodiesterase 3 (PDE3) inhibitor (IC₅₀ = 19.5 µM). It increases developed tension and contractile force in isolated cat papillary muscle. It also displays positive inotropic...

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Biovision | Lanreotide acetate | B2464

Lanreotide is a synthetic polypeptide analogue of somatostatin that resembles the native hormone in its ability to suppress levels and activity of growth hormone, insulin, glucagon and many other...

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Biovision | Indisulam | B2463

Indisulam is a novel sulfonamide antitumor agent that displays potent antitumor activity in vitro and in vivo. It affects cell cycle progression in human tumor cells. Indisulam also acts as a...

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Biovision | ARRY-797 | B2462

ARRY-797 is a potent and selective p38 mitogen-activated protein kinase inhibitor. Inhibits LPS-Induced IL-6 and In Vivo Growth of RPMI-8226 Human Multiple Myeloma Cells.ARRY-797 is a potent and...

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Biovision | BIBF-0775 | B2461

BIBF-0775 is a potent and selective transforming growth factor β (TGFβ) type I receptor (Alk5) inhibitor (IC₅₀ = 34 nM).BIBF-0775 is a potent and selective transforming growth factor β (TGFβ) type I...

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Biovision | PZ-2891 | B2460

PZ-2891 (PZ2891) a specific, allosteric, brain-permeable, pantothenate kinase (PANK) modulator. it acts as both an orthosteric inhibitor (IC₅₀ =1.3 nM, hPANK3) and an allosteric activator of PANK3...

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Biovision | HDM-201 | B2459

Siremadlin (NVP-HDM201) is a potent and highly specific MDM-2/p53 inhibitor. It binds to human MDM2 protein with a picomolar Ki value (0.21 nM). It activates p53 and induces robust p53-dependent cell...

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Biovision | Erdafitinib | B2458

Erdafitinib is a potent and selective orally bioavailable, pan fibroblast growth factor receptor (FGFR) inhibitor with potential antineoplastic activity. It inhibits FGFR1/2/3/4 with IC₅₀s of 1.2, 2...

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Biovision | Garenoxacin | B2457

Garenoxacin is a potent des-F(6)-quinolone antibacterial agent and a topoisomerase II inhibitor.Garenoxacin is a potent des-F(6)-quinolone antibacterial agent and a topoisomerase II inhibitor...

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Biovision | Vitamin A | B2456

Vitamin A is an intermediate in retinol metabolism in animals. It is metabolized to retinoic acid, a ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR). roles in...

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Biovision | Phytol | B2455

Phytol is a diterpene alcohol commonly used as an aromatic ingredient in many fragrance compounds. Phytol and its metabolites have been reported to activate retinoid X receptors (RXRs) and to promote...

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Biovision | LXR-623 | B2454

LXR-623 is a potent and selective LXR (liver X receptor) agonist. Reduces total serum cholesterol and LDL cholesterol, and inhibits lesion growth in models of atherosclerosis. Increases ABCA1 and...

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Biovision | BTK Inhibitor II | B2453

BTK inhibitor II is a potent Bruton's tyrosine kinase (BTK) inhibitor.BTK inhibitor II is a potent Bruton's tyrosine kinase (BTK) inhibitor.Biovision | B2453 | BTK Inhibitor II DataSheetAlternate...

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Biovision | GSK-626616 | B2452

GSK-626616 is a potent and selective DYRK inhibitor (IC₅₀ = 0.7 nM); inhibits other members of the DYRK family, e.g., DYRK1A and DYRK2, with similar potency. Displays ~20-fold selectivity over casein...

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Biovision | Trypsin Substrate (Colorimetric) | B2451

A chromogenic trypsin substrate. Trypsin cleaves p-nitroanilide (pNA) releasing p-nitroanilne that can be quantified using a spectrophotometer or a microtiter plate reader at ~ 405 nm.Ac-GPK-pNA is a...

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Biovision | KL001 | B2449

KL001 is a cryptochrome protein (CRY) stabilizer. It blocks ubiquitin-dependent degradation of CRY, resulting in lengthening of the circadian period. Represses glucagon-induced hepatic...

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Biovision | Carmofur | B2448

Carmofur is derivative of 5-flurouracil (Cat. No. B1519) that acts as an inhibitor of acid ceramidase (IC₅₀ = 79 nM for the rat enzyme). It reduces acid ceramidase activity in a dose- and...

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Biovision | Carglumic acid | B2447

Carglumic acid is an activator of carbamoyl phosphate synthetase 1 (CPS1), the first enzyme in the urea cycle that is responsible for removal and detoxification of ammonia, making this drug a...

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Biovision | Anagrelide | B2446

Anagrelide is a phosphodiesterase 3 (PDE3) inhibitor (IC₅₀ = 36 nM) with antiplatelet activity. Anagrelide inhibits the maturation of megakaryocytes into platelets, reducing both megakaryocyte...

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Biovision | Amsacrine | B2445

Amsacrine is a potent DNA intercalating and an antineoplastic agent. One of the ways amsacrine works is by blocking an enzyme topoisomerase 2. It is effective in the treatment of acute leukemias and...

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Biovision | Altretamine | B2444

Altretamine is an alkylating agent with antineoplastic and antiproliferative activity. It also acts as a chemosterilant for male houseflies and other insects.Altretamine is an alkylating agent with...

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Biovision | 9-Cis-Retinoic acid | B2443

9-cis Retinoic acid is an agonist at retinoic acid receptors (RARs) and retinoic X receptors (RXRs). 9-cis Retinoic acid also inhibits adipogenesis. In lymphatic endothelial cells, 9-cis retinoic...

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Biovision | Carboxyatractyloside Potassium salt | B2442

Carboxyatractyloside is a plant-derived natural heteroglucoside that prevents mitochondrial ATP synthesis by inhibiting ADP/ATP translocases, which are responsible for the exchange of adenine di- and...

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Biovision | Atractyloside Potassium salt | B2441

Atractyloside is an extremely toxic glycoside isolated from thistles. It blocks mitochondrial ATP synthesis by inhibiting ADP/ATP translocases, which are responsible for the exchange of adenine di-...

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Biovision | Atuveciclib | B2440

Atuveciclib (BAY-1143572) is a potent and selective CDK9/P-TEFb inhibitor (IC₅₀ = 6 nM for CDK9/CyclinT1); displays >150-fold selectivity over CDK1/2/3/5/6/7 (IC₅₀ >800 nM). Exhibits anticancer...

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Biovision | Tenalisib | B2439

Tenalisib is a potent, and selective PI3Kδ and PI3Kγ inhibitor with IC₅₀ values of 25 and 33 nM, respectively. Displays good selectivity over p110α (>300-fold) and p110β (>100-fold) isoforms...

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Biovision | INCB057643 | B2438

INCB057643 is a potent and selective BET inhibitor; displays more effectivity against androgen-dependent (VCaP and LNCaP) than androgen-independent (DU145 and PC3) cells with IC50 of 500 nM,...

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Biovision | Adavivint | B2437

Adavivint is a potent and selective Wnt pathway inhibitor with an EC₅₀ of 3 nM in vitro; induces hMSC differentiation into mature, functional chondrocytes and decreases cartilage catabolic marker...

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Biovision | IDF-11774 | B2436

IDF-11774 is a potent hypoxia-inducible factor (HIF)-1 inhibitor (IC₅₀ = 3.65 μM)IDF-11774 is a potent hypoxia-inducible factor (HIF)-1 inhibitor (IC₅₀ = 3.65 μM)Biovision | B2436 | IDF-11774...

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Biovision | Leniolisib | B2435

Leniolisib is a potent and selective PI3Kδ inhibitor with an IC₀ of 11 nM; displays >20-fold, 40-fold, and 200-fold selectivity over PI3Kα, PI3Kβ, and PI3Kγ, respectively; shows 30-fold cellular...

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Biovision | EX-229 | B2434

EX-229 is a potent and allosteric activator of AMP-activated protein kinase (AMPK). In rat epitrochlearis muscle, ex229 dose-dependently increases AMPK activity of α1-, α2-, β1- and β2-containing...

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Biovision | EBI-2511 | B2433

EBI-2511 is a highly potent and orally active EZH2 inhibitor with an IC₅₀ of 4 nM for EZH2(A667G). EBI-2511 displays excellent in vivo efficacy in Pfeiffer tumor Xenograft models in mouse and could...

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Biovision | LIT-927 | B2432

LIT-927 is a locally and orally active CXCL12 neutraligand (Ki = 267 nM for CXCL12-TR binding). Displays anti-inflammatory effect in a murine model of allergic airway hypereosinophilia.LIT-927 is a...

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Biovision | MK-3903 | B2431

MK-3903 is a potent and selective AMP-activated protein kinase (AMPK) activator (EC₅₀ = 8 nM).MK-3903 is a potent and selective AMP-activated protein kinase (AMPK) activator (EC₅₀ = 8 nM).Biovision |...

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Biovision | HS-1371 | B2430

HS-1371 is a potent RIP3 kinase inhibitor (IC₅₀ = 20.8 nM). It binds to the ATP binding pocket of RIP3 and inhibits ATP binding to prevent RIP3 enzymatic activity in vitro. . It inhibits TNF-induced...

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Biovision | TH-34 | B2429

TH-34 is a HDAC inhibitor that displays selectivity for HDACs 6, 8 and 10 over HDACs 1, 2 and 3. TH34 induces DNA damage-mediated cell death in human high-grade neuroblastoma cell lines.TH-34 is a...

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Biovision | Rilpivirine hydrochloride | B2427

Rilpivirine hydrochloride is a diarylpyrimidine derivative that acts as a reverse transcriptase inhibitor with antiviral activity against HIV-1. Rilpivirine is associated with a low rate of transient...

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Biovision | GSK-2814338 | B2426

GSK-2814338 is a potent Lp-PLA2 inhibitor useful for the treatment of atherosclerosis and Alzheimer's diseaseGSK-2814338 is a potent Lp-PLA2 inhibitor useful for the treatment of atherosclerosis and...

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Biovision | GSK-269962 hydrochloride | B2425

GSK-269962 is a potent and selective Rho kinase (ROCK) inhibitor (IC₅₀ values are 1.6 and 4 nM for recombinant human ROCK1 and ROCK2 respectively). It displays >30-fold selectivity for ROCK against a...

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Biovision | BIIE 0246 | B2424

BIIE 0246 is a potent, selective and competitive non-peptide antagonist for the neuropeptide Y Y2 receptor (IC₅₀ = 15 nM). BIIE 0246 displays > 650-fold selectivity over Y1, Y4 and Y5 receptors.BIIE...

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Biovision | Terbinafine (Free base) | B2423

Terbinafine is an allylamine antifungal agent that acts as a squalene epoxidase inhibitor.Terbinafine is an allylamine antifungal agent that acts as a squalene epoxidase inhibitor.Biovision | B2423 |...

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Biovision | Naftifine hydrochloride | B2422

Naftifine hydrochloride is an allylamine compound that displays antifungal and antimycotic activities. It inhibits fungal squalene epoxidase and prevents ergosterol biosynthesis. Naftifine also shows...

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Biovision | Butenafine hydrochloride | B2421

Butenafine is a potent antifungal agent that has broad-spectrum activity against 87 strains of dermatophytes. Butenafine works by inhibiting the synthesis of sterols by inhibiting squalene epoxidase,...

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Biovision | BMS-986142 | B2420

BMS-986142 is a potent, selective, and reversible BTK (Bruton’s tyrosine kinase) inhibitor (BTK IC₅₀ = 0.5nM; human WB IC₅₀ = 90 nM). BMS-986142 displays robust efficacy in murine models of...

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