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Biovision

  • Vicriviroc Malate

    Biovision | Vicriviroc Malate | 1599

    Second generation orally active CCR5 antagonist, which is also a potent inhibitor of HIV-1 entry into target cells, with a mean IC₅₀ =0.46 nM and IC₉₀ =1~10 nM to HIV isolates (n=52).Vicriviroc...

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  • Veratridine

    Biovision | Veratridine | 2422

    Veratridine is a steroidal alkaloid. Voltage-gated Na⁺ channel opener. May be used to increase Na⁺ concentration in cardiomyocytes and in cultured sympathetic neurons.Veratridine is a steroidal...

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  • Valrubicin (AD-32)

    Biovision | Valrubicin (AD-32) | B1833

    Valrubicin is a cytotoxic chemotherapeutic agent that is used as an intravesical agent for BCG-refractory carcinoma in situ (CIS) of the urinary bladder.Valrubicin is a cytotoxic chemotherapeutic...

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  • Valinomycin

    Biovision | Valinomycin | 2238

    A highly selective K⁺- ionophore. It binds potassium ions (K⁺) and facilitates their transfer across lipid bilayers. Inhibits Ca²⁺-ATPase activity and promotes cell death by mitochondrial swelling...

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  • Validamycin A

    Biovision | Validamycin A | B1540

    Validamycin A is an antifungal agent used to protect rice plants against sheath blight caused by the pathogenic fungus, R. solani, due to its ability to inhibit trehalase, a trehalose-hydrolizing...

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  • USP14 Inhibitor, IU1

    Biovision | USP14 Inhibitor, IU1 | 1845

    A cell-permeable, reversible and selective inhibitor of the deubiquitinating activity of human USP14 (IC₅₀ = 4-5 µM). IU1 promotes cell survival during proteotoxic stress and selectively stimulates...

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  • Urolithin A

    Biovision | Urolithin A | B1155

    Urolithin A is generated by gut microflora as a natural metabolite of ellagitannins, a class of compounds found in the pomegranate and other fruits and nuts. Oral administration of urolithin A leads...

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  • UNC-926, free base

    Biovision | UNC-926, free base | B2158

    UNC-926 is a methyl-lysine (Kme) reader domain inhibitor; it binds to the MBT domain of the L3MBTL1 protein (Kd = 3.9 μM). Selectively inhibits the L3MBTL13XMBT-H4K20me1 interaction in a peptide pull...

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  • UNC-669

    Biovision | UNC-669 | 2620

    UNC-669 is a small molecule nicotinamide derivative that acts asan antagonist of the MBT(Malignant Brain Tumor) domain, a family of methyl-lysine binding reader proteins. UNC669 displays selectivity...

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  • UNC-3866

    Biovision | UNC-3866 | B2361

    UNC-3866 is a potent and selective antagonist of CBX4 and CBX7 chromodomains with (Kd ≈ 100 nM). It is 6- to 63-fold selective for these chromodomains over the other CBX and CDY chromodomains...

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  • UNC2170

    Biovision | UNC2170 | 2889

    UNC-2170 is a micromolar ligand for the Methyl-lysine Binding Protein, 53BP1. UNC-2170 displays 17-fold selectivity for 53BP1 as compared to other methyl-lysine (Kme) binding proteins tested. It...

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  • UNC-2025

    Biovision | UNC-2025 | B1262

    UNC-2025 is a potent inhibitor of the tyrosine kinases Mer and Flt3 (IC₅₀s = 0.74 and 0.80 nM, respectively). It less potently inhibits Axl and Tyro3 (IC₅₀s = 14 and 17 nM, respectively) and a panel...

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  • UNC0631

    Biovision | UNC0631 | 2605

    UNC0631 is a potent and selective inhibitor of G9a activity in vitro (IC₅₀ = 4 nM) and G9a/GLP-mediated dimethylation of histone 3 on lysine 9 in MDA-MB-231 cells (IC₅₀ = 25 nM). It potently inhibits...

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  • UNC 1215

    Biovision | UNC 1215 | 2252

    Cell-permeable. A potent and selective chemical probe for the methyllysine (Kme) reading function of L3MBTL3, a member of the malignant brain tumor (MBT) family of chromatin-interacting...

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  • UF 010

    Biovision | UF 010 | B1146

    UF 010 is class I HDAC inhibitor that displays >6- fold selectivity over other HDACs. It has an IC₅₀ value of 0.06, 0.1, and 1.5 μM for HDACs 3, 2, 1 and 8 respectively. In vitro experimental data...

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  • U-93631

    Biovision | U-93631 | B1851

    U-93631 is a GABAA receptor antagonist. U-93631 causes rapid decay of gamma-aminobutyric acid-induced chloride currents in recombinant rat gamma-aminobutyric acid type A receptors.U-93631 is a GABAA...

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  • U-73343

    Biovision | U-73343 | B1888

    U-73343 is a structural analog of U-73122 (Cat. No. B1887) that does not inhibit PLC, making it useful as a negative control for PLC inhibition. Cell-permeable.U-73343 is a structural analog of...

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  • U-18666A

    Biovision | U-18666A | 9469

    U-18666A is a cell-permeable cholesterol trafficking inhibitor. It inhibits cholesterol transport from late endosomes/lysosomes to the endoplasmic reticulum (ER), but not cholesterol transport to the...

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  • Tyloxapol

    Biovision | Tyloxapol | B1158

    Tyloxapol is a nonionic liquid polymer of the alkyl aryl polyether alcohol type that is used as a surfactant to aid liquefaction. Tyloxapol is used in the development of non-ionic surfactant-based...

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  • TX1-85-1

    Biovision | TX1-85-1 | B1313

    TX1-85-1 is the first selective Her3 (ErbB3) ligand. TX1-85-1 forms a covalent bond with Cys721 located in the ATP-binding site of Her3.TX1-85-1 is the first selective Her3 (ErbB3) ligand. TX1-85-1...

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  • Tubastatin A

    Biovision | Tubastatin A | 1724

    Cell-permeable. A potent and selective HDAC6 (histone deacetylase 6) inhibitor. Displays 1093-fold selectivity over HDAC1 (IC₅₀ values of 15 nM for HDAC6 vs 16.4 µM for HDAC1). Tubastatin A was...

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  • TRX818

    Biovision | TRX818 | B1223

    TRX818 is an orally bioavailable agent with potential antineoplastic and anti-vasculogenic mimicry (VM) activities. TRX-818, upon oral administration appears to induce cancer cell apoptosis and...

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  • Troviridine

    Biovision | Troviridine | B1212

    Trovirdine is a potent inhibitor of HIV-1RT with IC₅₀ of 7 nM when employing heteropolymeric primer or template (oligo-DNA/ribosomal RNA) and dGTP as substrate.Trovirdine is a potent inhibitor of...

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  • Tripolin A

    Biovision | Tripolin A | 2307

    A specific non-ATP competitive Aurora A kinase inhibitor. Does not significantly inhibit Aurora B kinase in mammalian cells. Reduces localization of pAurora A on spindle microtubules (MTs), affects...

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  • Traut's Reagent

    Biovision | Traut's Reagent | 2330

    KEY FEATURES & APPLICATIONS: • Water-soluble • Adds a 5-atom spacer arm (8.1 Å) to minimize steric hindrance • The spacer is cleavable at the disulfide bond with reducing agent, such as DTT,...

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  • trans-ISRIB

    Biovision | trans-ISRIB | B1906

    trans-ISRIB is an integrated stress response inhibitor. Potently reverses the effects of initiation factor 2α (eIF2α) phosphorylation (IC₅₀ = 5 nM). Enhances spatial and fear-associated learning in...

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  • TPX-0005

    Biovision | TPX-0005 | B2027

    TPX-0005 is a potent ALK inhibitor. It inhibits WT ALK (IC50 1.01 nM) and mutant ALKs including ALK G1202R (IC₅₀ = 1.26 nM) and ALK L1196M (IC₅₀ = 1.08 nM). Moreover, TPX-0005 effectively inhibits...

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  • TP-0903

    Biovision | TP-0903 | 9590

    TP-0903 is a potent and selective AXL Inhibitor (IC₅₀ = 27 nM). TP-0903 induces massive apoptosis in CLL B cells with LD₅₀ values of nanomolar ranges. Treatment of cancer cells with TP-0903 reverses...

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  • TNB

    Biovision | TNB | 2482

    TNB is a useful standard when using DTNB (Ellman’s reagent) for the quantification of thiol (-SH) groups in a sample.TNB is a useful standard when using DTNB (Ellman’s reagent) for the quantification...

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