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Biovision

  • TMP-195

    Biovision | TMP-195 | B1860

    TMP-195 is a potent and selective class IIa HDAC inhibitor with IC₅₀ values of 59, 60, 26, and 15 nM for HDAC4, HDAC5, HDAC7 and HDAC9 respectively. TMP195 induces the recruitment and differentiation...

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  • TMP-153

    Biovision | TMP-153 | B1181

    TMP-153 is a selective inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT) with IC₅₀ of 5 to 10 nM. It has potency to inhibit cholesterol esterification and reduces its influx into the plasma of...

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  • TLR2-IN-C29

    Biovision | TLR2-IN-C29 | B2121

    TLR2-IN-C29 is an inhibitor of TLR2/1 and TLR2/6 signaling. It is induced by synthetic and bacterial TLR2 agonists in human HEK-TLR2 and THP-1 cells, but only TLR2/1 signaling in murine macrophages...

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  • Timentin

    Biovision | Timentin | B1508

    Timentin is a mixrure (15:1) of Ticarcillin Disodium Salt/Potassium Clavulanate. It acts as a β-Lactamase inhibitor. Highly effective combination against gram negative bacteria such as Agrobacterium...

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  • Tiliroside

    Biovision | Tiliroside | 1879

    A naturally occurring flavonoid that shows anti-complement, anti-inflammatory and free radical scavenger activity. Inhibits the production of the inflammatory mediators nitric oxide (NO), TNF-α and...

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  • THZ1 hydrochloride

    Biovision | THZ1 hydrochloride | 9544

    THZ1 is a potent, cell-permeable, and selective covalent CDK7 inhibitor (IC₅₀ = 3.2 nM) that preferentially diminishes transcription in cancer cells. It displays unprecedented ability to target a...

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  • THZ1 (Free base)

    Biovision | THZ1 (Free base) | 9664

    THZ1 is a potent, cell-permeable, and selective covalent CDK7 inhibitor (IC₅₀ = 3.2 nM) that preferentially diminishes transcription in cancer cells. It displays unprecedented ability to target a...

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  • Thymoquinone

    Biovision | Thymoquinone | B2172

    Thymoquinone is a natural phytochemical that displays anti-inflammatory properties, blocking the synthesis of leukotrienes. It inhibits the growth of leukemia cells (IC₅₀= 1.5 μg/ml), inducing...

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  • Thio-NAD

    Biovision | Thio-NAD | 9483

    An analog of NAD. Use of Thio-NAD instead of NAD (Cat. No. 2734) as a substrate for NAD(+)-consuming enzymes is more advantageous since the reduced form of Thio-NAD exhibits a substantial increase in...

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  • Thiocolchicine

    Biovision | Thiocolchicine | 2213

    An antimitotic alkaloid. Tubulin polymerization and microtubule assembly inhibitor and axonal cytoskeleton modulator; apoptosis inducer. Thiocolchicine-dimers were shown to be potent topoisomerase I...

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  • TGR-1202

    Biovision | TGR-1202 | B1284

    TGR-1202 (also known as RP5264), is a highly specific inhibitor of PI3Kδ, targeting the δ isoform with nanomolar potency and several-fold selectivity over the α, β, and g isoforms of PI3K.TGR-1202...

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  • TG101348

    Biovision | TG101348 | 2314

    TG101348 is a potent, and selective inhibitor of JAK2 (IC₅₀ = 3 nM). It has a 35- and 334-fold selectivity over JAK3 and JAK1, respectively.TG101348 is a potent, and selective inhibitor of JAK2 (IC₅₀...

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  • TG100713

    Biovision | TG100713 | B1717

    TG100713 is a pan-PI3K inhibitor against PI3Kγ, PI3Kδ, PI3Kα and PI3Kβ.TG100713 is a pan-PI3K inhibitor against PI3Kγ, PI3Kδ, PI3Kα and PI3Kβ.Biovision | B1717 | TG100713 DataSheetAlternate...

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  • Tetrandine

    Biovision | Tetrandine | B2089

    Tetrandrine is a bisbenylisoquinoline alkaloid that displays very broad pharmacological actions, including anti-tumor activity. It enhances the cytotoxicity of MDR-related drugs via modulation of...

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  • Terpendole C

    Biovision | Terpendole C | 2214

    Isolated from Albophoma yamanashiensis. An acyl-CoA:cholesterol acyltransferase (ACAT) isozymes ACAT1 and ACAT2 inhibitor. Also acts as a tremorgen and cholesteryl ester (CE) synthesis inhibitor...

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  • TD-139

    Biovision | TD-139 | B2266

    TD-139 is a potent, synthetic inhibitor of galectin-3. TD-139 has high affinity for galectin-3 with a Kd of 14 nM and 10 nM for galectin-1, but low affinity for galectins 2, 4N, 4C, 7, 8N, or...

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  • TCS-359

    Biovision | TCS-359 | B2212

    TCS-359 is a potent, ATP-competitive inhibitor of FLT3 receptor tyrosine kinase (IC₅₀ = 42 nM) that displays selectivity over a range of other kinases. It blocks the proliferation of myelomonocytic...

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  • TCS OX2 29

    Biovision | TCS OX2 29 | B1838

    TCS OX2 29 is a potent and selective OX2 (Orexin-2) receptor antagonist (IC₅₀ = 40 nM). Displays >250-fold selectivity for OX2 over OX1 (Orexin-1) and >50 receptors, ion channels and transporters.TCS...

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  • TC-S 7010

    Biovision | TC-S 7010 | B1203

    TC-S 7010 is a potent and selective inhibitor of Aurora kinase A (IC₅₀ = 3.4 nM). It displays1000-fold selectivity for Aurora kinase A over Aurora kinase B. Displays antiproliferative activity in...

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  • TCID

    Biovision | TCID | 2204

    Cell-permeable. A potent and selective inhibitor of ubiquitin C-terminal hydrolase L3 (UCH-L3) (IC50 = 0.6 µM). Inhibits ubiquitin C-terminal hydrolase L1 (UCH-L1) only at higher concentrations (IC50...

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  • TC-H 106

    Biovision | TC-H 106 | B1148

    TC-H 106 is a class I Histone deacetylase (HDAC) inhibitor with IC₅₀ values of 150,370,760 and 5000 nM for HDAC1, 3, 2 and 8 respectively. TC-H 106 shows slow and tight binding inhibitory activity on...

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  • TCEP.HCl

    Biovision | TCEP.HCl | 1202

    A water-soluble, odorless, thiol-free reagent useful for the selective reduction of disulfides. Compared to DTT, TCEP is more stable, more effective and able to reduce disulfide bonds at lower pHs...

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  • TC-E 5003

    Biovision | TC-E 5003 | B1177

    TC-E 5003 is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor (IC₅₀ = 1.5 μM); displays no inhibitory activity against CARM1 and Set7/9 methyltransferases. Inhibits growth of MCF7a...

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  • TAS-120

    Biovision | TAS-120 | B2354

    TAS-120 is a novel, potent and highly selective FGFR inhibitor that irreversibly inhibits all four FGFR subtypes at nanomolar concentrations. It blocks the phosphorylation of FGFRs and impedes...

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  • TAK-700

    Biovision | TAK-700 | B2209

    TAK-700 is a potent and highly selective human 17,20-lyase inhibitor (IC₅₀ = 38 nM). Displays >1000-fold selectivity over other CYPs (e.g. 11-hydroxylase and CYP3A4). Displays antiandogen activity...

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  • TAK-063

    Biovision | TAK-063 | B1067

    TAK-063 is a highly potent, cell-permeable PDE10A inhibitor (IC₅₀ = 0.30 nM) with excellent selectivity (>15000-fold selective over other PDEs).TAK-063 is a highly potent, cell-permeable PDE10A...

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  • TAK 165

    Biovision | TAK 165 | 1951

    Cell-permeable. A potent inhibitor of the human epidermal growth factor receptor 2 (HER2) tyrosine kinase (IC₅₀ = 6 nM). Displays > 4000-fold selectivity over EGFR, FGFR, PDGFR, JAK1 and Src. TAK 165...

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  • TAE-226

    Biovision | TAE-226 | 9436

    TAE-226 is a potent ATP-competitive inhibitor of FAK and IGF-IR with potential anticancer activity. TAE-226 can block FAK and IGF-IR signaling pathways. TAE-226 inhibits the phosphorylation of FAK as...

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  • T5601640

    Biovision | T5601640 | B1097

    T5601640, also known as T56-LIMKi, has high specific inhibitory activity for LIMK2 and shows little or no activity with LIMK1. It decreases levels of phosphorylated coflin (p-coflin) inhibiting...

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  • Syrosingopine

    Biovision | Syrosingopine | B1323

    Syrosingopine is an inhibitor of the vesicular monoamine transporters. Recently, it has been shown that the anticancer activity of the widely used diabetic drug metformin is strongly potentiated by...

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  • SYK Inhibitor, R406

    Biovision | SYK Inhibitor, R406 | 9682

    R406 is a potent SYK (Spleen Tyrosine Kinase) inhibitor (IC₅₀ = 41 nM). R406 strongly inhibits SYK but not Lyn, and displays 5-fold less potency towards FLT3. R406 induces apoptosis in diffuse large...

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  • Syk Inhibitor

    Biovision | Syk Inhibitor | 1983

    Cell-permeable. An oxindole derivative that acts as a potent, reversible, and ATP-competitive Spleen tyrosine kinase (Syk) inhibitor (IC₅₀ = 14 nM). Has been shown to effectively inhibit...

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  • SYBR Green I

    Biovision | SYBR Green I | B1747

    SYBR Green I is a highly sensitive fluorescent DNA binding stain for staining of double stranded DNA (dsDNA) or oligonucleotides in agarose or polyacrylamide gels.SYBR Green I is a highly sensitive...

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  • SW-044248

    Biovision | SW-044248 | B1135

    SW-044248 is a selective Topoisomerase I inhibitor. It is extremely potent and selectively toxic to NSCLC killing ~15% of a 74 NSCLC cell lines. It was not toxic to immortalized human bronchial cell...

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  • SW-033291

    Biovision | SW-033291 | 9584

    SW-033291 is a potent inhibitor of 15-hydroxy prostaglandin dehydrogenase (15-PGDH) (Ki = ~0.1 nM). It rapidly increases the levels of PGE2 in bone marrow and other tissues in mice after...

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  • Suplatast tosylate

    Biovision | Suplatast tosylate | 2624

    Suplatast tosylate is a Th2 cytokine inhibitor and an immunomodulator. It suppresses eosinophil infiltration, IgE production, and allergic inflammation by suppressing the production of IL-4 and IL-5 ...

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