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Biovision

  • SAR-405

    Biovision | SAR-405 | B1286

    SAR-405 is a potent and selective PIK3C3/Vps34 inhibitor that prevents autophagy and synergizes with mTOR inhibition in tumor cells.SAR-405 is a potent and selective PIK3C3/Vps34 inhibitor that...

    $1,239 - $4,018
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  • SANT-2

    Biovision | SANT-2 | 1976

    Cell-permeable. A potent antagonist of Hedgehog (Hh) signaling pathway. Antagonizes smoothened receptor activity (KD = 12 nM) and inhibits SAG (Cat. No. 1939-500,1000) activity. SANT-2 should be a...

    $665 - $1,351
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  • SANT-1

    Biovision | SANT-1 | 1978

    Cell-permeable. A potent inhibitor of Sonic hedgehog (Shh) signaling; high affinity antagonist of smoothened activity (Kd = 1.2 nM). Inhibits smoothened agonist effects with an IC₅₀of 20 nM in...

    $690 - $1,635
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  • Salvinorin B

    Biovision | Salvinorin B | B1923

    Salvinorn B is a potent and selective κ-opioid DREADD (KORD) agonist (EC₅₀ = 11.8 nM). DREADDs are chemogenetic tools widely used to remotely control cellular signaling, neuronal activity, and...

    $718 - $1,985
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  • Ryuvidine

    Biovision | Ryuvidine | B1808

    Ryuvidine is a potent inhibitor of SET domain-containing protein 8 (SETD8) (IC₅₀ = 0.5 µM) that suppresses monomethylation of H4K20 in vitro. It displays weak inhibiton against cyclin-dependent...

    $777 - $2,209
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  • RWJ-67657

    Biovision | RWJ-67657 | B2098

    RWJ-67657 is a potent inhibitor of the MAP kinases p38α and p38β (IC₅₀s = 1 and 11 µM, respectively, in vitro); inactive against p38γ and p38δ, as well as several other kinases. RWJ-67657 blocks the...

    $949 - $2,898
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  • RVX-208

    Biovision | RVX-208 | 9408

    RVX-208 is a potent inhibitor of BET bromodomains. It increases apolipoprotein A-I and high-density lipoprotein cholesterol in vitro and in vivo.RVX-208 is a potent inhibitor of BET bromodomains. It...

    $665 - $1,754
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  • Ruthenium Red

    Biovision | Ruthenium Red | 2490

    Ruthenium red is an inhibitor of mitochondrial Ca²⁺ uniporter; also blocks cell membrane-located capsaicin-activated cation channels (IC₅₀ = 14 nM) and voltage-sensitive Ca²⁺ channels to inhibit...

    $718 - $1,985
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  • Rubratoxin A

    Biovision | Rubratoxin A | B1239

    Rubratoxin A is a mycotoxin and protein phosphatase 2A (PP2A) inhibitor. Does not inhibit PP1, PP2B, PTP1B, ALP and CIP. It causes suppression of tumor metastasis and reduction of primary tumor...

    $2,727 - $4,680
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  • RTA-402

    Biovision | RTA-402 | B1974

    RTA-402 is a synthetic triterpenoid compound with anti-inflammatory, antitumor and cytoprotective properties. RTA-402 is a potent nuclear factor erythroid 2-related factor 2 (Nrf2) activator. CDDO-Me...

    $777 - $2,209
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  • RSV-604

    Biovision | RSV-604 | B1846

    RSV-604 is a novel inhibitor of respiratory syncytial virus (RSV) replication (EC₅₀ = 0.86 uM). Potentially useful for the treatment of respiratory syncytial virus infections.RSV-604 is a novel...

    $1,008 - $3,129
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  • RSL3

    Biovision | RSL3 | B2303

    RSL3 is a glutathione peroxidase 4 (GPX4) inhibitor and an inducer of ferroptosis. RSL3 increases lipid peroxidase levels in vitro and inhibits tumor formation and progression in vivo.RSL3 is a...

    $1,411 - $4,589
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  • RSC133

    Biovision | RSC133 | B1086

    RSC-133 is an epigenetic modulator that effectively improves reprogramming of human somatic cells to pluripotent stem cells. Apparently, RSC-133 facilitates the reprograming by dual inhibition of...

    $1,351 - $4,277
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  • RS-504393

    Biovision | RS-504393 | B2406

    RS-504393 is a selective CCR2 chemokine receptor antagonist (IC₅₀ values are 98 nM and > 100 μM for inhibition of human recombinant CCR2 and CCR1 receptors respectively). Inhibits MCP-1 chemotaxis...

    $1,180 - $3,703
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  • RQ-002303078

    Biovision | RQ-002303078 | 9636

    RQ-00203078 is a potent, selective TRPM8 antagonist (IC₅₀ values are 5.3 and 8.3 nM for rat and human channels respectively). Displays >350-fold selectivity for TRPM8 over TRPV4, TRPV1 and TRPA1...

    $1,120 - $3,584
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  • Rose bengal

    Biovision | Rose bengal | 2587

    Cell-permeable. Rose Bengal is a polyhalogenated fluorescein derivative that acts as a potent inhibitor (K(i) = 19 nM) of glutamate uptake into isolated synaptic vesicles. This vesicular Glu uptake...

    $665 - $1,582
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  • Roscovitine

    Biovision | Roscovitine | 1950

    Cell-permeable. A potent inhibitor of p34cdc2 (IC₅₀ = 0.2 µM). Also inhibits p33cdk2 and p33cdk5.Roscovitine is a potent inhibitor of p34cdc2 (IC₅₀ = 0.2 µM). Also inhibits p33cdk2 and p33cdk5...

    $637 - $1,411
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  • Roridin E

    Biovision | Roridin E | B2129

    Roridin E is a macrocyclic trichothecanoid isolated from several fungi. It displays activity against arenavirus JUNIN (JUNV), the etiological agent of Argentine hemorrhagic fever.Roridin E is a...

    $1,120 - $1,694
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  • Robenacoxib

    Biovision | Robenacoxib | B1990

    Robenacoxib is a non-steroidal anti-inflammatory drug (NSAID), that acts as a potent and selective inhibitor of cyclooxygenase-2 (COX-2). Robenacoxib is a non-steroidal anti-inflammatory drug...

    $837 - $2,440
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  • RO5126766

    Biovision | RO5126766 | B1705

    Ro5126766 (CH5126766) is a potent and selective dual RAF/MEK inhibitor. For SK-MEL-28, SK-MEL-2, MIAPaCa-2, and SW480 cell lines, the IC50 is determined by WST-8 assay is 65, 28, 40, and 46 nM,...

    $1,411 - $4,732
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  • RO 20-1724

    Biovision | RO 20-1724 | 2042

    Cell-permeable. A potent,selective, cAMP-specific phosphodiesterase inhibitor (PDE IV, IC50 = 2 µM). Inhibits superoxide generation and platelet aggregation stimulated by arachidonic acid. Also...

    $690 - $1,754
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  • RKI-1313

    Biovision | RKI-1313 | B1092

    RKI-1313 weak inhibitor for ROCK2-dependent signaling and has less effect on phosphorylation levels of ROCK substrates. RKI-1313 serves as a negative control for RKI-1447 (Cat. No. 2472) which is a...

    $837 - $2,440
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  • RIPA Buffer

    Biovision | RIPA Buffer | 2114

    A ready-to-use buffer useful for lysing cells and tissues for radioimmunoprecipitation assay. RIPA buffer also results in low background in immunoprecipitation/pull down assays. The buffer (1X)...

    $865 - $2,555
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  • Rhapontigenin

    Biovision | Rhapontigenin | 2074

    A natural analog of resveratrol (Cat. No. 1758-100, 500) with antioxidant and anti-cancer activity. Rhapontigenin was found to scavenge intracellular reactive oxygen species (ROS), the...

    $690 - $1,838
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  • RG7388

    Biovision | RG7388 | 2577

    RG7388 is highly a potent and selective inhibitor of p53-MDM2 interaction. RG7388 blocks p53−MDM2 binding and effectively activates the p53 pathway, leading to cell cycle arrest and/or apoptosis in...

    $1,008 - $2,982
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  • RG-7112

    Biovision | RG-7112 | B1919

    RG-7112 is a Nutlin imidazoline compound that acts as a potent MDM2 inhibitor as well as displays antineoplastic activity. RG-7112 binds to MDM2, thereby preventing the binding of the MDM2 protein to...

    $777 - $2,209
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  • RG 108

    Biovision | RG 108 | 1679

    A DNA methyltransferase (DNMT) inhibitor. RG108 causes demethylation and reactivation of tumor suppressor genes, but it does not affect the methylation of centromeric satellite sequences. In...

    $980 - $1,925
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  • Retro-2

    Biovision | Retro-2 | 2516

    An inhibitor of ribosome-inactivating proteins (RIPs). At a concentration of 200 mg/kg, Retro-2 displayed full protection of mice against a dose of ricin that killed 90% of an unprotected control...

    $777 - $2,209
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  • Renin Inhibitor

    Biovision | Renin Inhibitor | 2084

    A non-peptide, direct renin inhibitor (IC50 = 0.6 nM for human renin) and an anti-hypertensive agent. Aliskiren confers neuronal resistance to Aβ toxicity in primary rat cortical cultures.Renin...

    $1,411 - $4,449
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  • Remogliflozin

    Biovision | Remogliflozin | B2082

    Remogliflozin is a potent sodium-glucose co-transporter subtype 2 (SGLT2) inhibitor with antihyperglycemic activity. Potential drug for treatment of type 2 diabetes.Remogliflozin is a potent...

    $837 - $2,440
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  • Radotinib

    Biovision | Radotinib | 9613

    Radotinib is a BCR-ABL1-specific second-generation tyrosine kinase inhibitor (TKI). Also inhibits PDGFR thereby blocking PDGFR-mediated signal transduction pathways. Displays antineoplastic...

    $1,120 - $3,584
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  • Radicicol

    Biovision | Radicicol | B1533

    Radicicol is an antifungal antibiotic that inhibits heat shock protein 90 (Hsp90) activity by binding to the ATP-binding pocket, subsequently suppressing cell transformation induced by src, ras and...

    $1,061 - $3,357
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  • R428

    Biovision | R428 | 9591

    R428 is a potent and selective small-molecule inhibitor (IC₅₀ = 14 nM) of the receptor tyrosine kinase Axl. R428 blocks Axl-dependent events, including Akt phosphorylation, breast cancer cell...

    $1,411 - $4,501
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  • Quinol 2

    Biovision | Quinol 2 | 2437

    A potent and selective antitumor agent that displays potent activity against renal, colon, and breast cancer cell lines in the NCI 60-cell panel. Shows potent antitumor activity in HCT 116 and HT 29...

    $1,008 - $3,070
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  • Quinol 1h

    Biovision | Quinol 1h | 2436

    A potent and selective antitumor agent that displays potent activity against renal, colon, and breast cancer cell lines in the NCI 60-cell panel. Exhibits a mean GI₅₀ of 16 nM and a mean LC₅₀ value...

    $1,120 - $3,413
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