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Biovision

  • PHA-767491(HCl)

    Biovision | PHA-767491(HCl) | B1639

    PHA-767491 is a potent and selective ATP-competitive dual cdc7/cdk9 inhibitor.PHA-767491 is a potent and selective ATP-competitive dual cdc7/cdk9 inhibitor.Biovision | B1639 | PHA-767491(HCl)...

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  • PF74

    Biovision | PF74 | B2369

    PF74 is a HIV-1 inhibitor that targets HIV capsid protein. PF74 binds specifically to HIV-1 particles and triggers premature HIV-1 uncoating in target cells. PF74 acts at an early stage of HIV-1...

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  • PF-562271 besylate

    Biovision | PF-562271 besylate | B1253

    F-562271 is an ATP-competitive, reversible inhibitor of FAK (IC₅₀ = 1.5 nM). It displays 10-fold reduced potency for PYK2 (IC₅₀ = 14 nM) and >100-fold selectivity against other protein kinases...

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  • PF-477736

    Biovision | PF-477736 | B2335

    PF-477736 is a potent, ATP-competitive inhibitor of Chk1 (checkpoint kinase 1) (Ki =0.49 nM). It displays 100-fold selectivity over Chk2. PF-477736 abrogates DNA damage-induced cell cycle arrest...

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  • PF-431396

    Biovision | PF-431396 | 2844

    PF-431396 is dual focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2) inhibitor with IC₅₀ values 2 and 11 nM respectively.PF-431396 is dual focal adhesion kinase (FAK) and...

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  • PF299804

    Biovision | PF299804 | 2678

    PF299804 (Dacomitinib) is a potent, irreversible pan-HER inhibitor with IC₅₀’s of 6, 46, and 74 nM for ErbB1(HER1), ErbB2 (HER2), and ErbB4 (HER4), respectively. PF299804 inhibits ErbB1...

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  • PF-06650833

    Biovision | PF-06650833 | B1558

    PF-06650833 is an inhibitor of Interleukin-1 receptor associated kinase 4 (IRAK4).PF-06650833 is an inhibitor of Interleukin-1 receptor associated kinase 4 (IRAK4).Biovision | B1558 | PF-06650833...

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  • PF-06463922

    Biovision | PF-06463922 | B1169

    PF-06463922 is a potent, selective, brain-penetrant, and high affinity ALK (Anaplastic lymphoma kinase) and ROS1 (c-Ros oncogene 1) inhibitor displaying >100-fold selectivity for ROS1 over panel of...

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  • PF-06409577

    Biovision | PF-06409577 | B2033

    PF-06409577 is a potent and selective allosteric activator of AMPK (EC₅₀ values are 7 and >40000 nM for AMPKα1β1γ1 and AMPKα1β2γ1, respectively). Displays minimal off-target effects on a panel of...

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  • PF-05212384

    Biovision | PF-05212384 | 9461

    PF-05212384 is a potent, selective and ATP-competitive dual inhibitor of PI 3-kinase/mTOR (IC₅₀ values are 0.4, 1.6 and 5.4 nM for PI 3-Kα, mTOR and PI 3-Kγ respectively). Exhibits selectivity over...

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  • PF-04981517

    Biovision | PF-04981517 | 2917

    Potent and selective inhibitor of CYP3A (IC50 = 30 nM (CYP3A4), 17 μM (CYP3A5) and 70 μM (CYP3A7).Potent and selective inhibitor of CYP3A (IC50 = 30 nM (CYP3A4), 17 μM (CYP3A5) and 70 μM (CYP3A7)...

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  • PF-04554878

    Biovision | PF-04554878 | 2888

    PF-04554878 is potent, ATP-competitive, focal adhesion kinase (FAK) inhibitor with potential antiangiogenic and antineoplastic activities. PF-04554878 inhibits FAK phosphorylation at the Tyr397 site...

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  • PF-03394197

    Biovision | PF-03394197 | 2883

    PF-03394197 is potent and selective Janus kinase (JAK) inhibitor. It inhibits JAK family members with an IC₅₀ of 10-99 nM being most potent against JAK1 (IC₅₀ = 10 nM). PF-03394197 does not inhibit a...

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  • Pepstatin A

    Biovision | Pepstatin A | 1732

    An inhibitor of acid proteases (aspartyl peptidases), e.g. pepsin, rennin, and cathepsin D. The inhibitor is highly selective and does not inhibit thiol proteases, neutral proteases, or serine...

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  • Penicillin G sodium

    Biovision | Penicillin G sodium | 2503

    Penicillin G sodium is a member of the β-lactam antibiotics. β-Lactams interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are...

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  • Penicillide

    Biovision | Penicillide | B1245

    Penicillide is an inhibitor of Acyl-Coenzyme A cholesterol acyltransferase (ACAT), Calpain and Oxytocin receptor. It has shown to have growth inhibition properties in plants and displays anticancer,...

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  • Pellitorine

    Biovision | Pellitorine | 2053

    Cell-permeable. A natural product isolated from the roots of Piper Nigrum. Modulator of the sensory neuron function to induce tingling parethesia. Excellent stable model compound for sensory studies...

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  • PD184352

    Biovision | PD184352 | 1585

    A highly potent ATP-noncompetitive MEK inhibitor. It inhibits MEK with an in vitro IC₅₀ of 1-1.3 nM. It does not inhibit other kinases. Highly recommended tool to inhibit MKK1 or MKK1 plus MKK5...

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  • PD-168393

    Biovision | PD-168393 | B2352

    PD-168393 is a cell-permeable, irreversible inhibitor of EGFR kinase activity (IC₅₀ = 0.70 nM). PD-168393 decreases the production of TNF-α and phosphorylation of ERK1/2 and p38 induced by LPS in...

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  • PD-146176

    Biovision | PD-146176 | B2313

    A specific, non-competitve 15-lipoxygenase (15-LOX) inhibitor (Ki = 197nM). Displays only weak effect on 5-LOX, 12-LOX, COX-1 or COX-2 (IC₅₀ = 0.54 μM for 15-LOX in rabbit reticulocytes).PD-146176 is...

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  • PD0332991

    Biovision | PD0332991 | 2843

    PD0332991 is a highly specific inhibitor of Cdk4 (IC₅₀ = 11 nM) and Cdk6 (IC₅₀ = 16 nM). Displays selectivity for Cdk4/6 over a panel of 34 additional protein kinases (IC₅₀ values are > 10 μM)...

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  • PD-0325901

    Biovision | PD-0325901 | 1643

    A selective and ATP non-competitive MEK inhibitor that suppresses the phosphorylation of ERK in murine colon 26 tumors (IC₅₀ = 0.33 nM). In combination with the GSK-3 inhibitor CHIR99021, prevents...

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  • PD 173074

    Biovision | PD 173074 | 1675

    A potent and selective FGFR1 tyrosine kinase inhibitor (IC₅₀ = 21.5 nM). Blocking of the FGFR signaling pathway by PD 173074 leads to self-renewal of stem cells via ERK1/2 activation. Treatment of...

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  • PD 150,606

    Biovision | PD 150,606 | 1906

    Cell-permeable. A selective, non-competitive Calpain inhibitor (Ki = 210 nM and 370 nM for Calpain-1 and Calpain-2, respectively). Interacts with the calcium-binding domain of calpain.PD 150, 606 is...

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  • PCI 34051

    Biovision | PCI 34051 | 2251

    PCI 34051 is a potent histone deacetylase 8 (HDAC8) inhibitor (IC₅₀ = 0.01 μM) with >200-fold selectivity over HDAC isoforms 1, 2, 3, 6, and 10 (IC₅₀s = 4, >50, >50, 2.9, and 13 μM, respectively)...

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  • PBTZ169

    Biovision | PBTZ169 | B1205

    PBTZ169 is a decaprenyl-phosphoribose-epimerase (DprE1) inhibitor. DprE1 is an an essential enzyme involved in the cell wall biosynthesis of Corynebacterineae.PBTZ169 is a...

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  • Parecoxib Sodium

    Biovision | Parecoxib Sodium | B1989

    Parecoxib sodium is an injectable prodrug of valdecoxib, that acts as a potent and selective inhibitor of cyclooxygenase-2 (COX-2). Useful for the short-term treatment of postoperative pain in adults...

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  • Pamidronate disodium

    Biovision | Pamidronate disodium | 1884

    A bisphosphonate compound that inhibits bone resorption, the natural, ongoing process of bone being destroyed by osteoclasts. Also inhibits farnesyl diphosphate synthase (IC₅₀ = 200 nM).Pamidronate...

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  • P529

    Biovision | P529 | 2462

    A potent PI3K/Akt/mTOR inhibitor that inhibits the TORC1 and TORC2 complexes. Displays inhibition of both Akt signaling and mTOR signaling similarly in tumor and vasculature. P529 inhibits tumor...

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  • P5091

    Biovision | P5091 | 2277

    Cell-permeable. A Selective inhibitor of the ubiquitin-specific protease USP7 (IC₅₀ = 4.2 µM). Induces apoptosis in multiple myeloma cells and overcomes bortezomib resistance. Displays antiangiogenic...

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