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Biovision

  • OXA-01

    Biovision | OXA-01 | 2695

    OXA-01 is an ATP-competitive, selective dual inhibitor of mTORC1/mTORC2. Displays antiangiogenic and antitumor properties.OXA-01 is an ATP-competitive, selective dual inhibitor of mTORC1/mTORC2...

    $1,008 - $3,129
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  • Ouabain

    Biovision | Ouabain | B2068

    Ouabain is a cardioactive glycoside consisting of rhamnose and ouabagenin, obtained from the seeds of Strophanthus gratus and other plants of the Apocynaceae. Acts as a potent and selective Na⁺/K⁺...

    $718 - $1,754
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  • OTX015

    Biovision | OTX015 | 2651

    OTX015 is a potent inhibitor of BRD2, BRD3, and BRD4 (EC₅₀s = 10-19 nM). It displays antiproliferative effects at a sub-micromolar range in vitro in a wide range of solid tumor types and leukemias,...

    $949 - $2,898
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  • OSU-03012

    Biovision | OSU-03012 | 2295

    A novel celecoxib derivative, that acts as a potent inhibitor of 3-phosphoinositide-dependent kinase-1 (PDK1) activity (IC₅₀ = 5 µM for recombinant PDK1). It displays anti-cancer activity in a...

    $777 - $2,209
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  • OSMI-1

    Biovision | OSMI-1 | B1916

    OSMI-1 is a potent, cell-permeable, O-GlcNAc transferase (OGT) inhibitor. inhibits protein O-GlcNAcylation in several mammalian cell lines without qualitatively altering cell surface N- or O-linked...

    $1,208 - $3,644
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  • OSI-420

    Biovision | OSI-420 | B2201

    OSI-420 is an active metabolite of Erlotinib (Cat. No. 1588) which is an orally active EGFR tyrosine kinase inhibitor with IC₅₀ of 2 and 20 nM for the inhibition of human EGFR and EGFR...

    $718 - $1,866
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  • Oseltamivir Acid

    Biovision | Oseltamivir Acid | B1886

    Oseltamivir acid (GS-4071) is the active metabolite of oseltamivir (Cat. No. B1885). It acts as an inhibitor of influenza neuraminidases A and B (IC₅₀ = 0.1 to 4.9 nM for both enzymes), in this way...

    $718 - $1,866
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  • ORY-1001

    Biovision | ORY-1001 | B1957

    ORY-1001 is a potent and selective inhibitor of LSD1 (IC₅₀ < 20 nM). It targets acute myeloid leukemia (AML) stem cells and significantly reduces tumor cell load while increasing survival time in...

    $837 - $2,440
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  • ONO-4059 analog

    Biovision | ONO-4059 analog | B1897

    ONO4059-Analog is a structural analogue of ONO-4059 that acts as a potent and selective BTK (Bruton's tyrosine kinase) inhibitor.ONO4059-Analog is a structural analogue of ONO-4059 that acts as a...

    $1,120 - $3,584
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  • ONO-4059

    Biovision | ONO-4059 | B1283

    ONO-4059 is a highly selective, orally bioavailable BTK (Bruton’s Tyrosine Kinase) inhibitor with a potency an IC₅₀ of 2.2 nM.ONO-4059 is a highly selective, orally bioavailable BTK (Bruton’s...

    $1,008 - $3,129
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  • ONO 1078

    Biovision | ONO 1078 | B1099

    ONO-1078 is a novel leukotriene antagonist that inhibits and reverses human bronchial contraction induced by leukotrienes C4 and D4 and antigen in vitro. It also shows concentration dependent...

    $718 - $1,985
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  • Okadaic acid

    Biovision | Okadaic acid | 1543

    A Potent inhibitor of protein phosphatases 1 and 2A in numerous cell types. Does not affect activity of acid phosphatase, alkaline phosphatase and tyrosine phosphatase. Non-phorbol type tumor...

    $858 - $1,694
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  • OG-L002

    Biovision | OG-L002 | 9406

    OG-L002 is a potent and specific inhibitor of Lysine Specific Demethylase-1(LSD-1) (IC₅₀ of 20 nM). Displays 36- and 69-fold selectivity over MAO-B and MAO-A, respectively. It potently represses...

    $1,239 - $3,703
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  • ODQ

    Biovision | ODQ | 2051

    A specific inhibitor OF soluble guanylyl cyclase (sGC) (IC50 = 20 nM). ODQ is a useful and selective tool to elucidate the physiological importance of the NO-cGMP pathway.ODQ is a specific inhibitor...

    $749 - $2,209
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  • ODM-201

    Biovision | ODM-201 | 9668

    ODM-201 is a new-generation, potent and selective androgen receptor (AR) antagonist (Ki = 11 nM). In AR overexpressing HS-HEK293 cells, ODM-201 inhibits the androgen-induced nuclear translocation of...

    $1,120 - $3,584
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  • Obeticholic Acid

    Biovision | Obeticholic Acid | B1898

    Obeticholic acid is a derivative of cholic acid which acts as a potent and selective FXR (Farnesoid X receptor) agonist (EC₅₀ = 99 nM) displaying anticholeretic activity in an in vivo rat model of...

    $777 - $2,037
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  • O412

    Biovision | O412 | B1150

    O4I2 is a potent Oct3/4 inducer in various human cell lines including human fibroblasts. O4I2 might be a useful tool for induction of pluripotency in somatic cells.O4I2 is a potent Oct3/4 inducer in...

    $777 - $2,156
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  • O411

    Biovision | O411 | B1149

    O4I1 is potent inducer of Oct3/4 (Octamer–binding transcription factor) and enhances the expression and stabilization of Oct 3 & 4 in neonatal fibroblasts. It also increases the transcriptional...

    $777 - $2,156
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  • Nystatin, USP

    Biovision | Nystatin, USP | B1509

    Nystatin is a polyene antifungal antibiotic produced by Streptomyces noursei. Nystatin acts by binding to ergosterols in fungal cell membranes, increasing permeability of the membrane, and creating...

    $837 - $3,703
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  • NXY-059

    Biovision | NXY-059 | 9487

    NXY-059 is a free radical trapping neuroprotectant. Displays neuroprotection in several animal models of acute ischemic stroke.NXY-059 is a free radical trapping neuroprotectant. Displays...

    $1,008 - $3,129
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  • NVS-SM1

    Biovision | NVS-SM1 | B1844

    NVS-SM1, also known as LMI070, is a highly potent, selective small molecule SMN2 splicing modulator with potential for treating spinal muscular atrophy. It works by increasing the amount of...

    $1,292 - $4,277
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  • NVP-BKM120

    Biovision | NVP-BKM120 | 2619

    NVP-BKM120 is a potent inhibitor of class I PI3K isoforms; potently blocks both p110α (IC₅₀ = 52 nM) and p110β (IC₅₀ = 166 nM) in vitro. It is much less effective against the class III PI3K Vps34 and...

    $777 - $2,209
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  • NVP-BGJ398

    Biovision | NVP-BGJ398 | 2855

    NVP-BGJ398 is a potent and selective, pan-FGFR kinase inhibitor. It inhibits the proliferation of various FGFR-dependent cell lines at nano-molar concentrations including breast and lung cancers...

    $1,008 - $3,129
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  • NVP-BEP800

    Biovision | NVP-BEP800 | B2198

    NVP-BEP800 is a potent oral inhibitor of Hsp90β (IC₅₀ = 58 nM). Displays strong anti-proliferative activity against various tumor cell lines and primary tumors in vitro and in vivo at well-tolerated...

    $777 - $2,209
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  • NVP-AUY922

    Biovision | NVP-AUY922 | 1591

    A Hsp90 inhibitor. NVP-AUY922 has excellent potency against Hsp90 in a fluorescence polarization binding assay with an IC₅₀ of 21 nmol/L against the β-isoform and of 13 nmol/L for the α-isoform...

    $2,065 - $5,677
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  • NVP-231

    Biovision | NVP-231 | B2225

    NVP-231 is a potent and reversible inhibitor of ceramide kinase (CerK) (IC₅₀ = 12 nM). It displays selectivity for CerK over sphingosine kinases (IC₅₀ ≥100 μM) and other lipid kinases.NVP-231 is a...

    $718 - $1,866
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  • Nutlin-3b

    Biovision | Nutlin-3b | B1227

    Nutlin-3b is less potent (+)-enantiomer of Nutlin-3 as p53 MDM2 inhibitor in comparison with more potent opposite (-)-enantiomer Nutlin-3a. Nutlin-3b may be used as negative control for non-MDM2...

    $718 - $1,985
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  • Nutlin-3

    Biovision | Nutlin-3 | 1842

    Cell-permeable. Nutlin-3 is a Mdm2 (mouse double minute 2) antagonist (IC₅₀ = 90 nM for Nutlin-3a and 13.6 µM for Nutlin-3b), p53 pathway activator, and apoptosis inducer.Nutlin-3 is a Mdm2 (mouse...

    $690 - $1,754
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  • script

    Biovision | script | 2186

    A Negative control compound for the histone deacetylase (HDAC) inhibitor Scriptaid (Cat. No. 1605-1).script is a negative control compound for the histone deacetylase (HDAC) inhibitor Scriptaid (Cat...

    $865 - $2,555
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  • NU-7441

    Biovision | NU-7441 | B1117

    NU-7441 is a potent and selective DNA-PK inhibitor (IC₅₀ = 14 nM). Displays selectivity for DNA-PK over a range of kinases including mTOR, PI 3-K, ATM and ATR. Also enhances CRISPR-Cas9-mediated...

    $949 - $2,898
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  • NU6102

    Biovision | NU6102 | 2313

    A potent inhibitor of CDK1 and CDK2 with Ki values of 9 and 6 nM and IC₅₀ values of 9.5 and 5.4 nM, respectively. Selective for CDK1 and CDK2 compared to CDK4/D1 (IC₅₀ = 1.6 μM), DYRK1A (IC₅₀ = 0.9...

    $665 - $1,754
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  • NU 1025

    Biovision | NU 1025 | 2351

    A potent poly(ADP-ribose) polymerase (PARP) inhibitor (IC₅₀ = 400 nM). Useful to study the regulation of deoxyribonucleic acid repair by PARP enzyme.NU 1025 is a potent poly(ADP-ribose) polymerase...

    $637 - $1,411
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  • NSC-87877

    Biovision | NSC-87877 | 2687

    NSC-87877 is a cell-permeable inhibitor of both SHP-1 and SHP-2 protein tyrosine phosphatases (IC₅₀ = 355 and 318 nM, respectively). It is much less effective against other protein tyrosine...

    $718 - $1,925
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  • NSC-697923

    Biovision | NSC-697923 | B1091

    NSC-697923 is a selective Ub-conjugating enzyme (E2) complex Ubc13-Uev1A inhibitor. Inhibits the formation of the Ubc13~Ub conjugate. NF-κB activation inhibitor. Inhibits proliferation and survival...

    $837 - $2,440
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  • NSC-687852

    Biovision | NSC-687852 | 2021

    Cell-permeable. Abrogates the deubiquitinating activity of the 19S regulatory particle by inhibiting ubiquitin C-terminal hydrolase 5 (UCHL5) and ubiquitin-specific peptidase 14 (USP14) resulting in...

    $718 - $3,500
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  • NSC-663284

    Biovision | NSC-663284 | B1809

    NSC-663284 is a potent, selective and irreversible inhibitor of all Cdc25 isoforms, with preference for Cdc25A (IC₅₀ = 29, 95, and 89 nM for Cdc25A, Cdc25B2, and Cdc25C, respectively). Displays > 20-...

    $777 - $2,209
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  • NSC-59984

    Biovision | NSC-59984 | B1052

    NSC-59984 is a p53 pathway activator that induces mutant p53 protein degradation via MDM2 and the ubiquitin-proteasome pathway. The EC₅₀ of NSC-59984 in most cancer cells is significantly lower than...

    $837 - $2,440
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  • NSC-5844

    Biovision | NSC-5844 | B1122

    NSC-5844 is a bisquinoline molecule that displays C-C chemokine receptor type 1 (CCR1) agonistic properties.NSC-5844 is a bisquinoline molecule that displays C-C chemokine receptor type 1 (CCR1)...

    $1,008 - $3,129
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  • NSC-348884

    Biovision | NSC-348884 | B1204

    NSC-348884 is a nucleophosmin inhibitor that disrupts oligomer formation and induces apoptosis, inhibits cell proliferation at an IC₅₀ of 1.4-4.0 μM in distinct cancer cell lines.NSC-348884 is a...

    $949 - $2,898
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