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Product Description
HMGB2 polyclonal Antibody | BS90651 | Bioworld
Host: Rabbit
Reactivity: Human, Mouse, Rat
Application: WB ICC IHC
Application Range: WB:1:500-1:1,000 ICC:1:50-1:200 IHC:1:50-1:200
Background: High mobility group (HMG) proteins 1 and 2 are ubiquitous non-histone components of chromatin. Evidence suggests that the binding of HMG proteins to DNA induces alterations in the DNA architecture including DNA bending and unwinding of the helix. HMG proteins synergize with Oct-2, members of the NFκB family, ATF-2 and c-Jun to activate transcription. Other studies indicate that phosphorylation of HMG protein is required to stimulate the transcriptional activity of the protein. Human HMG-1 and HMG-2 both contain two DNA-binding domains, termed HMG boxes. HMG proteins bind single-stranded DNA but induce conformational changes in double-stranded DNA alone.
Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Specificity: HMGB2 polyclonal Antibody detects endogenous levels of HMGB2 protein.
Molecular Weight: 24 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: HMG-2, HMGB2, HMG2, C80539, High mobility group (nonhistone chromosomal) protein 2, High mobility group box 2, High mobility group protein 2, High mobility group protein B2, HMG 2, HMG B2, HMG-2, HMG2, HMGB2, HMGB2,
Immunogen: Recombinant protein.
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: Protein affinity purified.
Pathway:
