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Product Description
Ki67 polyclonal Antibody | BS90769 | Bioworld
Host: Rabbit
Reactivity: Human, Mouse, Rat
Application: WB,IHC,IF
Application Range: WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Background: Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly. Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the chromosome surface. Prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility. Binds DNA, with a preference for supercoiled DNA and AT-rich DNA. Does not contribute to the internal structure of mitotic chromosomes. May play a role in chromatin organization. It is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in maintaining mitotic chromosomes dispersed (Probable) .
Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Specificity: Ki67 polyclonal Antibody detects endogenous levels of Ki67 protein.
Molecular Weight: 359 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: Antigen KI-67, Antigen Ki67, MKI67, Antigen identified by monoclonal Antibody Ki 67, Antigen identified by monoclonal Antibody Ki-67, Antigen KI-67, Antigen KI67, Antigen Ki67, KI67, KIA, Marker of proliferation Ki-67, MIB 1, MIB, MKI67, PPP1R105, Proliferation marker protein Ki-67, Proliferation related Ki 67 antigen, Protein phosphatase 1 regulatory subunit 105, RP11-380J17.2,
Immunogen: Peptide
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: Peptide affinity purified
Pathway:
