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Product Description
NUP98 monoclonal Antibody | MB0111 | Bioworld
Host: Mouse
Reactivity: Human
Application: WB IP
Application Range: WB: 1:1000 IP: 1:50~1:200
Background: Signal-mediated nuclear import and export proceed through the nuclear pore complex (NPC), which is comprised of approximately 50 unique proteins collectively known as nucleoporins. The 98 kDa nucleoporin is generated through a biogenesis pathway that involves synthesis and proteolytic cleavage of a 186 kDa precursor protein. This cleavage results in the 98 kDa nucleoporin as well as a 96 kDa nucleoporin, both of which are localized to the nucleoplasmic side of the NPC. Rat studies show that the 98 kDa nucleoporin functions as one of several docking site nucleoporins of transport substrates. The human gene has been shown to fuse to several genes following chromosome translocations in acute myelogenous leukemia (AML) and T-cell acute lymphocytic leukemia (T-ALL) . This gene is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described.
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: This Antibody detects endogenous levels of NUP98 and does not cross-react with related proteins
Molecular Weight: Predicted band size:98kDa Observed band size:98kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: Nuclear pore complex protein Nup98; 98 kDa nucleoporin; Nucleoporin Nup98; Nuclear pore complex protein Nup96; 96 kDa nucleoporin; Nucleoporin Nup96; ADIR2; NUP96; NUP196
Immunogen: Recombinant full length Human NUP98.
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: The Antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Pathway:
