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Product Description
CD177 polyclonal Antibody | BS6857 | Bioworld
Host: Rabbit
Reactivity: Human,Mouse
Application: WB
Application Range: WB 1:500 - 1:2000
Background: Patients with polycythemia vera (PV), a neoplastic stem cell disorder that leads to excessive production of all myeloid cell lines, overexpress the cell surface antigen CD177, also designated NB1. The increased output, especially of red blood cells, increases whole blood viscosity and causes vascular occlusion and ischemia. Because of the marked upregulation of CD177 in PV patients, as compared to healthy individuals or those with other erythrocytosis-related conditions, analysis of this protein presents a useful tool for diagnosis and research into the mechanisms of PV.
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: CD177 polyclonal Antibody detects endogenous levels of CD177 protein.
Molecular Weight: ~ 46 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: CD177 antigen; Human neutrophil alloantigen 2a; HNA-2a; NB1 glycoprotein; NB1 GP; Polycythemia rubra vera protein 1; PRV-1; CD177; CD177; NB1; PRV1; UNQ595; PRO1181
Immunogen: Recombinant full length Human CD177.
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Pathway:
