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Product Description
Islet 1 polyclonal Antibody | BS90744 | Bioworld
Host: Rabbit
Reactivity: Human, Mouse
Application: WB ICC/IF IP
Application Range: WB:1:1,000 ICC:1:50-1:200
Background: Islet-1 (ISL1 transcription factor, LIM/homeodomain) and Islet-2 (ISL2 transcription factor, LIM/homeodomain) contain amino-terminal LIM domains and a carboxy-terminal homeodomain and both influence developmental events. Islet-1 influences embryogenesis of the pancreatic islets of Langerhans and neural tube motor neuron differentiation. In developing mouse teeth, Islet-1 mediates patterning of dentition as an activator of Bmp4 expression in incisor (distal) areas of the stomatodeal epithelium. Islet-1 expression defines cardiac progenitor cell populations and is required for normal cardiac development and asymmetry. Islet-2 activity in newly generated motor neurons permits the diversification of visceral and somatic motor neuron subtypes in the developing spinal cord. Murine Islet-2 specifies retinal ganglion cell (RGC) laterality by repressing an ipsilateral pathfinding program unique to the ventral-temporal crescent (VTC) of RGCs in a Zic2- and EphB1-dependent manner.
Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Specificity: Islet 1 polyclonal Antibody detects endogenous levels of Islet 1 protein.
Molecular Weight: 39 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: Islet-1, ISL1, Insulin gene enhancer protein ISL 1, Insulin gene enhancer protein ISL-1, Insulin related protein, ISL 1, ISL LIM homeobox 1, ISL1, ISL1 transcription factor LIM homeodomain, ISL1 transcription factor, LIM/homeodomain (islet 1), ISL1 transcription factor, LIM/homeodomain, ISL1, Islet-1, Islet1,
Immunogen: recombinant protein
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: ProA affinity purified
Pathway:
