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Product Description
JAK2 polyclonal Antibody | BS90750 | Bioworld
Host: Rabbit
Reactivity: Human, Mouse, Rat
Application: ICC IHC
Application Range: ICC:1:50-1:200 IHC:1:50-1:200
Background: JAK2 (Janus kinase 2) belongs to the emerging family of non-receptor Janus tyrosine kinases, which regulate a spectrum of cellular functions downstream of activated cytokine receptors in the lympho-hematopoietic system. Immunological stimuli, such as interferons and cytokines, induce recruitment of Stat transcription factors to cytokine receptor-associated JAK2. JAK2 then phosphorylates proximal Stat factors, which subsequently dimerize, translocate to the nucleus and bind to cis elements upstream of target gene promoters to regulate transcription. The canonical JAK/Stat pathway is integral to maintaining a normal immune system by stimulating proliferation, differentiation, survival and host resistance to pathogens. Altering JAK/Stat signaling to reduce cytokine induced pro-inflammatory responses represents an attractive target for anti-inflammatory therapies.
Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Specificity: JAK2 polyclonal Antibody detects endogenous levels of JAK2 protein.
Molecular Weight: 131 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: JAK-2, JAK2, JAK 2, JAK-2, JAK2, JAK2, Janus Activating Kinase 2, Janus kinase 2 (a protein tyrosine kinase), Janus kinase 2, JTK 10, JTK10, kinase Jak2, OTTHUMP00000043260, THCYT3, Tyrosine protein kinase JAK2, Tyrosine-protein kinase JAK2,
Immunogen: Peptide.
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: Peptide affinity purified.
Pathway:
