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Product Description
NFkB p105/p50 polyclonal Antibody | BS90939 | Bioworld
Host: Rabbit
Reactivity: Human, Mouse, Rat
Application: WB IHC
Application Range: WB:1:1,000-1:5,000 IHC:1:50-1:200
Background: Proteins encoded by the v-Rel viral oncogene and its cellular homolog, c-Rel, are members of a family of transcription factors that include the two subunits of the transcription factor NF B (p50 and p65) and the Drosophila maternal morphagen, dorsal. These proteins share sequence homology over a region of 300 amino acids at their NH2-terminus, the region that contains their DNA binding and dimerization domains. The DNA binding activity of NF B is activated and rapidly transported from the cytoplasm to the nucleus in cells exposed to mitogens or growth factors. cDNAs encoding precursors for two distinct proteins have been described. These proteins, designated p105 and p100, are highly related but map on different chromosomes. The p105 (p110) precursor contains p50 at its N-terminus and a C-terminal region that when expressed as a separate molecule, designated PdI, binds to p50 and regulates its activity.
Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Specificity: NFkB p105/p50 polyclonal Antibody detects endogenous levels of NFkB p105/p50 protein.
Molecular Weight: 50/105 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: NFKB1, DKFZp686C01211, DNA binding factor KBF1, DNA binding factor KBF1 EBP1, DNA-binding factor KBF1, EBP 1, EBP-1, EBP1, KBF1, MGC54151, NF kappa B, NF kappaB, NF kappabeta, NF kB1, NFkappaB, NFKB 1, NFKB p105, NFKB p50, Nfkb1, NFKB1, Nuclear factor kappa B DNA binding subunit, Nuclear factor kappa-B, subunit 1, Nuclear factor NF kappa B p105 subunit, Nuclear factor NF kappa B p50 subunit, Nuclear factor NF-kappa-B p50 subunit, Nuclear factor of kappa light chain gene enhancer in B cells 1, Nuclear factor of kappa light polypeptide gene enhancer in B cells 1, Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105, p50, p84/NF-kappa-B1 p98, Transcription factor NFKB1,
Immunogen: recombinant protein
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: ProA affinity purified
Pathway: T cell receptor signaling,Toll-like Receptor signaling,
