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Product Description
BACE (D492) polyclonal Antibody | BS1382 | Bioworld
Host: Rabbit
Reactivity: Human,Mouse,Rat
Application: IHC IF
Application Range: IHC: 1:50~1:200 IF: 1:50~1:200
Background: Autosomal dominant Alzheimer’s disease is caused by mutations in the gene encoding the β-amyloid protein precursor (APP) . Amyloid β-peptide (Aβ), the major feature of amyloid plaques in Alzheimer’s patients, is the product of APP cleavage by β- and γ-secretases. BACE is the transmembrane protease which cleaves Aβ from APP. BACE and the related protein Asp1 are both widely expressed in human tissue with the highest levels in the pancreas. BACE has a molecular mass of ~70 kDa, larger than predicted due to glycosylation, and is localized within Golgi and endosomes.
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: BACE (D492) polyclonal Antibody detects endogenous levels of BACE protein.
Molecular Weight: ~ 50 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: Beta-secretase 1; Aspartyl protease 2; ASP2; Asp 2; Beta-site amyloid precursor protein cleaving enzyme 1; Beta-site APP cleaving enzyme 1; Memapsin-2; Membrane-associated aspartic protease 2; BACE1; BACE; KIAA1149
Immunogen: Synthetic peptide, corresponding to amino acids 480-520 of Human BACE.
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Pathway: Signaling Pathways Activating p38 MAP Kinase,Examples of Crosstalk Between Post-translational Modifications,
![BACE/Asp2 (CT) Antibody [Polyclonal] | PC-071](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/500x659/products/391315/569778/klogo__76714.1643661101__83847.1644059243.png?c=2 "BACE/Asp2 (CT) Antibody [Polyclonal] | PC-071")
