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Product Description
Bim polyclonal Antibody | BS90137 | Bioworld
Host: Rabbit
Reactivity: Human
Application: WB ICC IHC IP
Application Range: WB:1:1,000-1:2,000 ICC:1:50-1:200 IHC:1:50-1:200
Background: Pro-apototic Bcl-2 family members promote cell death by neutralizing their anti-apoptotic relatives, which otherwise maintain cell viability by regulating caspase activity. Bim belongs to the BH3-only subgroup of Bcl-2 related proteins, and exists in three distinct isoforms, BimS (short), BimL (long) and BimEL (extra long) . ERK1/2 phosphorylates BimEL, resulting in rapid degradation of the isoform via the proteasome pathway. At least three sites for ERK1/2 phosphorylation exist on BimEL, whereas ERK1/2 does not effect BimS and BimL, implying a unique role for BimEL in cell survival signaling.
Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Specificity: Bim polyclonal Antibody detects endogenous levels of Bim protein.
Molecular Weight: 22/16/13 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: Bcl2-L-11, BCL2L11, BCL2 like 11, B2L11, BAM, Bcl 2 interacting protein Bim, Bcl 2 related ovarian death agonist, Bcl-2-like protein 11, BCL2 interacting mediator of cell death, BCL2 like 11 (apoptosis facilitator), BCL2 like protein 11, Bcl2-interacting mediator of cell death, Bcl2-L-11, Bcl2l11, BIM alpha6, BIM, BIM beta6, BIM beta7, BimEL, BimL, BOD,
Immunogen: recombinant protein
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: ProA affinity purified
Pathway:
![Bim Antibody [Polyclonal] | PC-033](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/500x659/products/391291/569754/klogo__76714.1643661101__35228.1644059240.png?c=2 "Bim Antibody [Polyclonal] | PC-033")
