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Product Description
BLNK (N91) polyclonal Antibody | BS2547 | Bioworld
Host: Rabbit
Reactivity: Human,Mouse
Application: IHC
Application Range: IHC: 1:50~1:200
Background: B-cell linker protein (BLNK, also known as SLP65, BASH, and BCA) is a B cell adaptor that plays an important role in B cell development and in BCR-signal transduction. Since BLNK does not encode any intrinsic enzymatic activity, its function is to serve as a scaffold for assembling macromolecular complexes which includes enzymes (PLC gamma, Vav and Btk) and additional linker proteins (Grb2 and Nck) (1-3) . In addition, BLNK binds Btk and is required for activation of the transcription factor NF-κB. Tyrosine phosphorylation of BLNK by Syk provides specific docking sites for these SH2-containing effector proteins which in turn permits phosphorylation and/or activation of their respective signaling pathways.
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: BLNK (N91) polyclonal Antibody detects endogenous levels of BLNK protein.
Molecular Weight: ~ 68,70 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: B-cell linker protein; BASH; BASH; Bca; Bca; BLNK; BLNK s; BLNK; Cytoplasmic adapter protein; Ly 57; Ly 57; Ly57; Lymphocyte antigen 57; Lymphocyte antigen 57; Lyw 57; Lyw57; Lyw57; MGC111051; SLP 65; SLP 65; SLP-65; SLP65;
Immunogen: Synthetic peptide, corresponding to amino acids 60-107 of Human BLNK.
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Pathway:
