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Product Description
Catenin α1 polyclonal Antibody | BS90196 | Bioworld
Host: Rabbit
Reactivity: Human, Mouse, Rat
Application: WB ICC/IF IHC IP FC
Application Range: WB:1:1,000-1:2,000 ICC:1:50-1:200 IHC:1:50-1:200 FC:1:50-1:100
Background: α E-catenin (also designated α-catenin; cadherin-associated protein, α1, 102 kDa; and CAP102) plays a role in E-cadherin mediated cell-cell adhesion by linking E-cadherin to the cytoskeleton via β- or γ-catenin and Actin. α E-catenin connects cell-density-dependent adherens junctions with the developmental hedgehog pathway and may provide a negative feedback loop controlling the size of developing cerebral cortex. It is abundant in neuroepithelial precursor cells in the developing cortical ventricular zone of the brain, with reduced expression in the cortical plate. α E-catenin-vinculin interactions play a role in the assembly of the apical junction complex in epithelia. Catenins generally are thought to work as connectors that anchor E-cadherin to the cytoskeletal Actin bundle through the cadherin cytoplasmic domain. Dysfunction of this adhesion complex causes dissociation of cancer cells from primary tumor nodules, thus possibly contributing to cancer invasion and metastasis.
Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Specificity: Catenin α1 polyclonal Antibody detects endogenous levels of Catenin α1 protein.
Molecular Weight: 100 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: CTNNA1, Alpha E-catenin, Cadherin associated protein 102kDa, Cadherin associated protein, Cadherin-associated protein, CAP 102, CAP102, Catenin (cadherin associated protein) alpha 1 102kDa, Catenin (cadherin associated protein), alpha 1, 102kDa, Catenin alpha 1, Catenin alpha-1, CTNA1, CTNNA 1, Ctnna1, FLJ36832, FLJ52416, NY REN 13 antigen, OTTHUMP00000224141, OTTHUMP00000224147, Renal carcinoma antigen NY REN 13, Renal carcinoma antigen NY-REN-13,
Immunogen: recombinant protein
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: ProA affinity purified
Pathway: Wntβ catenin signaling，Adherens Junction signaling,
