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Product Description
Cdk6 polyclonal Antibody | BS90284 | Bioworld
Host: Rabbit
Reactivity: Human
Application: WB ICC/IF IHC FC
Application Range: WB:1:1,000-1:2,000 ICC:1:50-1:200 IHC:1:50-1:200 FC:1:50-1:100
Background: Cell cycle progression is controlled in part by a family of cyclin proteins and cyclin dependent kinases (Cdks) . Cdk proteins work in concert with the cyclins to phosphorylate key substrates involved in each phase of cell cycle progression. Another family of proteins, Cdk inhibitors, also plays a role in regulating the cell cycle by binding to cyclin-Cdk complexes and modulating their activity. Several Cdk proteins have been identified, including Cdk2-Cdk8, PCTAIRE-1-PCTAIRE-3, PITALRE and PITSLRE. Cdk6 is known to associate with cyclins D1, D2 and D3 and to be involved with the G1/S transition of the cell cycle. Multiple inhibitors of Cdk6 have been identified, including p18 and p19. These inhibitors bind to both free and complexed Cdk6, and they inhibit the activity of the cyclin D-bound Cdk6.
Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Specificity: Cdk6 polyclonal Antibody detects endogenous levels of Cdk6 protein.
Molecular Weight: 37 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: CDK6, CDK 6, CDK6, CDK6, Cell division protein kinase 6, Crk 2, Crk2, Cyclin dependent kinase 6, Cyclin-dependent kinase 6, MGC59692, p40, PLSTIRE, Serine/threonine protein kinase PLSTIRE, Serine/threonine-protein kinase PLSTIRE, STQTL11,
Immunogen: recombinant protein
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: ProA affinity purified
Pathway:
