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Product Description
CENPC polyclonal Antibody | BS90294 | Bioworld
Host: Rabbit
Reactivity: Human
Application: WB ICC IF IHC FC IP
Application Range: WB:1:500-1:2,000 ICC:1:50-1:200 IHC:1:50-1:200 FC:1:50-1:200 IP:1:10-1:50
Background: A replicated chromosome includes two kinetochores that control chromosome segregation during mitosis. The evolutionarily conserved Centromere Protein-C, CENP-C, is a kinetochore assembly protein. CENP-C is located on the fibers of the kinetochore and constitutes a kinetochore organizing center that tightly associates with DNA. CENP-C is necessary for the formation of a functional centromere, which indicates that CENP-C is important for mitotic progression. In addition, CENP-C is lost from centromeres during herpes simplex virus 1 infection, causing substantial structural changes in the kinetochore, which suggests that the structure of CENP-C is regulated during the cell cycle.
Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.
Specificity: CENPC polyclonal Antibody detects endogenous levels of CENPC protein.
Molecular Weight: 107 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: CENP-C, CENP-C 1, CENP-C 1, CENP-C, CENPC, CENPC1, Centromere autoantigen C, Centromere autoantigen C1, Centromere protein C 1, Centromere protein C, hcp-4, ICEN7, Interphase centromere complex protein 7, MIF2,
Immunogen: Recombinant protein within human CENPC aa 400-600.
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: ProA affinity purified
Pathway:
