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Product Description
Crystallin αB polyclonal Antibody | BS90335 | Bioworld
Host: Rabbit
Reactivity: Human, Rat
Application: WB IHC ICC/IF IP
Application Range: WB:1:500-1:2,000 ICC:1:50-1:200 IHC:1:50-1:200 IP:1:50
Background: Crystallins are the major proteins of the vertebrate eye lens, where they maintain the transparency and refractive index of the lens. Crystallins are divided into α, β and γ families, and the β- and γ-crystallins also compose a superfamily. Crystallins usually contain seven distinct protein regions, inclu-ding four homologous motifs, a connecting peptide, and N- and C-terminal extensions. α-crystallins consist of three gene products, αA-, αB- and αC-crystallin, which are members of the small heat shock protein family (HSP 20) . α-crystallins act as molecular chaperones by holding denatured proteins in large soluble aggregates. However, unlike other molecular chaperones, α-crystallins do not renature these proteins. Expression of αA-crystallin is restricted to the lens and defects of this gene cause the development of autosomal dominant congenital cataracts (ADCC) . The human αB-crystallin gene product is expressed in many tissues, including lens, heart and skeletal muscle. Elevated expression of αB-crystallin is associated with many neurological diseases, and a missense mutation in this gene has co-segregated in a family with a Desmin-related myopathy.
Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Specificity: Crystallin αB polyclonal Antibody detects endogenous levels of Crystallin αB protein.
Molecular Weight: 20 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: HspB5, CRYAB, CRYA2, HSPB5, AACRYA, Alpha B crystallin, Alpha crystallin B chain, Alpha (B) -crystallin, Alpha-crystallin B chain, CRYA2, Cryab, CRYAB, Crystallin alpha B, Crystallin alpha polypeptide 2, CTPP2, Heat shock 20 kD like protein, Heat shock protein beta 5, Heat shock protein beta-5, HspB5, Renal carcinoma antigen NY REN 27, Renal carcinoma antigen NY-REN-27, Rosenthal fiber component,
Immunogen: recombinant protein
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: ProA affinity purified
Pathway:
