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Product Description
Cytokeratin 16 polyclonal Antibody | BS90377 | Bioworld
Host: Rabbit
Reactivity: Human
Application: WB ICC/IF IHC FC
Application Range: WB:1:1,000-1:2,000 ICC:1:50-1:200 IHC:1:50-1:200 FC:1:50-1:100
Background: Cytokeratins comprise a diverse group of intermediate filament proteins that are expressed as pairs in both keratinized and non-keratinized epithelial tissue. The cytokeratin proteins play a critical role in differentiation, as well as tissue specialization and function, to maintain the overall structural integrity of epithelial cells. Cytokeratins are also useful markers in identifying the origin of metastatic tumors. Cytokeratin 16 is expressed in benign stratified squamous epithelium and squamous cell carcinoma of the head and neck, as well as luminal cells of mammary gland and sweat ducts. It is absent in noninvasive breast carcinomas and normal breast tissue. Mutations in the Cytokeratin 16 gene cause various diseases, including pachyonychia congenita type 1 (PC1), nonepidermolytic palmoplantar keratoderma (NEPPK) and unilateral palmoplantar verrucous nevus (UPVN) .
Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Specificity: Cytokeratin 16 polyclonal Antibody detects endogenous levels of Cytokeratin 16 protein.
Molecular Weight: 51 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: CK-16, K16, CK 16, CK-16, CK16, Cytokeratin-16, Cytokeratin16, FNEPPK, Focal non epidermolytic palmoplantar keratoderma, K 16, K16, K1C16, K1CP, Keratin 1 type I, Keratin 16, Keratin, Keratin type I cytoskeletal 16, Keratin-16, Keratin16, KRT 16, Krt16, KRT16A, NEPPK, PC1, type I cytoskeletal 16,
Immunogen: recombinant protein
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: ProA affinity purified
Pathway:
