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Product Description
EB3 polyclonal Antibody | BS90441 | Bioworld
Host: Rabbit
Reactivity: Human, Mouse, Rat
Application: WB ICC IF IHC FC
Application Range: WB:1:500-1:1,000 ICC:1:50-1:200 IHC:1:50-1:200 FC:1:50-1:100
Background: EB1 (MAPRE2, microtubule-associated protein, RP/EB family, member 2, EB2, RP1) may influence tumorigenesis of colorectal cancers and proliferative control of normal cells. EB1 may belong to the intermediate/early gene family, involved in the signal transduction cascade downstream of the TCR. Colorectal cancer is caused by the pathologic transformation of normal colonic epithelium to an adenomatous polyp, which can become an invasive cancer. APC (adenomatous polyposis coli) is a tumor suppressor gene, the mutation of which is one of the earliest events in colorectal carcinogenesis. A majority of the mutations result in the loss of the carboxy terminus of APC. EB1 has been shown to bind to the carboxy terminal region of APC, which implicates EB1 in APC suppression of colonic cancer. EB1 overexpression may play a role in the development of human esophageal squamous cell carcinoma (ESCC) by affecting APC function and activating the beta-catenin/TCF pathway. EB3 is related to EB1 and likewise associates with the microtubule cytoskeleton. EB3 is expressed predominantly in the central nervous system and preferentially associates with APCL.
Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Specificity: EB3 polyclonal Antibody detects endogenous levels of EB3 protein.
Molecular Weight: 32 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: EBF3, EB3, MAPRE3, APC binding protein, EB 3, EB1 protein family member 3, EB3, EBF 3, EBF3, EBF3 S, End binding protein 3, End-binding protein 3, MAPRE 3, MAPRE3, MARE3, Member 3, Microtubule Associated Protein, Microtubule associated protein RP/EB family member 3, Microtubule-associated protein RP/EB family member 3, OTTHUMP00000200910, RP 3, RP/EB Family, RP3,
Immunogen: Recombinant protein
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: ProA affinity purified
Pathway:
