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Product Description
ERα (phospho-S118) polyclonal Antibody | BS4071 | Bioworld
Host: Rabbit
Reactivity: Human,Mouse,Rat
Application: IHC
Application Range: IHC:1:50~1:200
Background: Estrogen receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of ligand-activated transcription factors. Estrogen receptors, including ERα and ERβ, contain DNA binding and ligand binding domains and are critically involved in regulating the normal function of reproductive tissues. They are located in the nucleus, though some estrogen receptors associate with the cell surface membrane and can be rapidly activated by exposure of cells to estrogen. ERα and ERβ have been shown to be differentially activated by various ligands. Receptor-ligand interactions trigger a cascade of events, including dissociation from heat shock proteins, receptor dimerization, phosphorylation and the association of the hormone activated receptor with specific regulatory elements in target genes. Evidence suggests that ERα and ERβ may be regulated by distinct mechanisms even though they share many functional characteristics.
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: p-ERα (S118) polyclonal Antibody detects endogenous levels of ERα protein only when phosphorylated at Ser118
Molecular Weight: ~ 66 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: Estrogen receptor; ER-alpha; ER; ESR1; ESR; NR3A1
Immunogen: Synthetic phosphopeptide derived from human ERα around the phosphorylation site of Serine 118.
Conjugate: Unconjugated
Modification: Phosphorylation
Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Pathway: Contribution of ECM and Cytoskeletal Factors to EMT,B cell receptor signaling,
