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Product Description
GAK (Q129) polyclonal Antibody | BS1871 | Bioworld
Host: Rabbit
Reactivity: Human,Mouse
Application: IHC
Application Range: IHC: 1:50~1:200
Background: Cyclin D1 accumulates during G1 and associates with Cdk2, Cdk4 and Cdk5. Cyclin E and Cdk2 interact during the G1 to S transition. Cyclin G contains a typical N terminal cyclin box and a carboxy terminal domain sequence homologous to the tyrosine phosphorylation site of the epidermal growth factor receptor) . Cyclin G expression is induced within 3 hours after growth stimulation and remains elevated with no apparent cell cycle dependency. A serine/threonine kinase, designated GAK for cyclin G associated kinase, has been identified. GAK has been shown to bind directly to cyclin G and to co-immunoprecipitate with Cdk5, which also associates with cyclin G.
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: GAK (Q129) polyclonal Antibody detects endogenous levels of GAK protein.
Molecular Weight: ~ 143 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: Cyclin-G-associated kinase
Immunogen: Synthetic peptide, corresponding to amino acids 101-150 of Human GAK.
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Pathway:
