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Product Description
GCNT7 (N349) polyclonal Antibody | BS3088 | Bioworld
Host: Rabbit
Reactivity: Human,Mouse,Rat
Application: IHC IF
Application Range: IHC: 1:50~1:200 IF: 1:50~1:200
Background: GCNT7, is a 430 amino acid glycosyltransferase that is localized to the Golgi apparatus. Other members of this family include GCNT1, GCNT2, GCNT3, GCNT4 and GCNT6. GCNT1 has been shown to play an important regulatory role in the biosynthesis of mucin-type O-glycans, which serve as ligands in cell adhesion. Specifically, GCNT1 expression in leukocytes regulates the synthesis of core 2 O-glycans that carry sialyl-Lewis x (sLex) oligosaccharides, which confer high affinity binding to Selectin proteins. Since downregulation of Selectin ligand expression has been shown to inhibit tissue infiltration, glycosyltransferase 14 family members represent potential drug targets for the treatment of inflammatory disorders and other pathologies involving Selectin proteins.
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: GCNT7 (N349) polyclonal Antibody detects endogenous levels of GCNT7 protein.
Molecular Weight: ~ 49 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: Beta-1;3-galactosyl-O-glycosyl-glycoprotein beta-1;6-N-acetylglucosaminyltransferase 7; C20orf105
Immunogen: Synthetic peptide, corresponding to amino acids 216-372 of Human GCNT7.
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Pathway:
