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Product Description
Monoclonal Antibodies to PIVKA-Ⅱ Clone1 | NBP0209-1 | Bioworld
Host: mouse
Expression: N/A
Tag: N/A
Isotype: IgG1 kappa
Determination Method: immunochromatography or chemiluminescent immunoassay
Application: N/A
General Information: Protein Induced by Vitamin K Absence or Antagonist-II (PIVKA-II), also known as Des-γ-carboxy-prothrombin (DCP), is an abnormal form of prothrombin. Normally, the prothrombin’s 10 glutamic acid residues (Glu) in the γ-carboxyglutamic acid (Gla) domain at positions 6, 7, 14, 16, 19, 20,25, 26, 29 and 32 are γ-carboxylated to Gla by vitamin-K dependent γ- glutamyl carboxylase in the liver and then secreted into plasma. In patients with hepatocellular carcinoma (HCC), γ-carboxylation of prothrombin is impaired so that PIVKA-II is formed instead of prothrombin. PIVKA-II is considered as is an efficient biomarker specific for HCC.
Recomendation: Capture-Clone2;detection-Clone3 or Capture-Clone2;detection-Clone4
Product Buffer: 20 mM PB, 150 mM NaCl, 0.1% Proclin 300,pH7.4
Purity: >95% as determined by SDS-PAGE.
Storage: Store it under sterile conditions at -20℃ to -80℃ upon receiving. Recommend to aliquot the protein into smaller quantities for optimal storage.
Specificity: Recognizes native PIVKA Ⅱ
Source: N/A
Molecular weight: N/A
Note: N/A
