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Product Description
PCYT1A Polyclonal Antibody | BS65679 | Bioworld
Host: Rabbit
Reactivity: Human,Mouse,Rat,Dog,Pig,Cow,Horse,Rabbit,Sheep,
Application: IHC-P,
Application Range: IHC-P=1:100-500
Background: Increase in fetal surfactant synthesis and lung maturity is caused by the glucocorticoidal induction of enzymes required for phosphatidylcholine synthesis towards the end of gestation (1) . The regulation of gestational age-dependent induction of phosphatidylcholine synthesis by glucocorticoids is still unclear (1) . The rate-controlling enzyme in the phosphatidylcholine biosynthetic pathway is CTP-phosphocholine cytidylyltransferase A (CCT A) (2–4) . In cultured eukaryotic cells, this enzyme is essential for survival (3) . The alpha isoform is located in the nucleus and is regulated by reversible phosphorylation and membrane association (3) . There is significant identity between the alpha-helical membrane-binding domains of CCT A and soybean oleosin (2) . Expressed CCT A has lipid-dependent cytidylyltransferase activity (5) . The gene which encodes CCT A maps to human chromosome 3q (4) .
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: PCYT1A Polyclonal Antibody detects endogenous levels of PCYT1A protein.
Molecular Weight: 42kD
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: CCT A; CCT alpha; CCT-alpha; Choline phosphate cytidylyltransferase A; Choline-phosphate cytidylyltransferase A; CT A; CT Antibody CTP:phosphocholine cytidylyltransferase A; CTPCT; PCY1A_HUMAN; PCYT1; Pcyt1a; Phosphate cytidylyltransferase 1 choline alpha; Phosphate cytidylyltransferase 1 choline alpha isoform; Phosphorylcholine transferase A.
Immunogen: KLH conjugated synthetic peptide derived from human PCYT1A
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: affinity purified by Protein A
Pathway:
