Euro
USD
British Pound
NULL
Product Description
Syk (F169) polyclonal Antibody | BS1343 | Bioworld
Host: Rabbit
Reactivity: Human
Application: IHC
Application Range: IHC: 1:50~1:200
Background: Syk (spleen tyrosine kinase) is a 635 amino acid protein that contains one protein kinase domain and two SH2 domains. One of several members of the protein kinase superfamily, Syk functions as a positive effector of B cell antigen receptor (CD79) -stimulated responses, coupling CD79 with the movement of one calcium ion through one of two phospho-regulated pathways. Via its ability to influence CD79 activity and to control the movement of calicum through the cell, Syk plays an important role in a variety of cellular responses, including differentiation, phagocytosis, proliferation and B cell development. Syk expression is upregulated in T cell lymphoma, suggesting a possible role for Syk in tumorigenesis. Two isoforms of Syk, designated short and long, exist due to alternative splicing events.
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: SYK (F169) polyclonal Antibody detects endogenous levels of SYK protein
Molecular Weight: ~ 72 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: Tyrosine-protein kinase SYK; Spleen tyrosine kinase; p72-Syk; SYK
Immunogen: Synthetic peptide, corresponding to amino acids 150-200 of Human Syk.
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Pathway: Immune Cell Signaling,B cell receptor signaling,
