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Product Description
TRP12/TRPV4 Polyclonal Antibody | BS65952 | Bioworld
Host: Rabbit
Reactivity: Human,Mouse,Rat,Chicken,Dog,Pig,Cow,
Application: FCM,
Application Range: Flow-Cyt=1ug/test
Background: The detection of noxious stimuli (chemical, mechanical, or thermal) occurs predominantly at the peripheral terminals of primary afferent neurons. This information is ultimately transmitted to the central nervous system to evoke appropriate protective reflexes. TRPV4 is a non selective calcium permeant, swell activated, cation channel probably involved in osmotic and mechano sensitivity. Activation by exposure to hypotonicity within the physiological range, low pH, citrate and phorbol esters exhibits an outward rectification. Once activated the channel seems to be regulated in a calmodulin dependent manner, with a negative feedback mechanism.
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: TRP12/TRPV4 Polyclonal Antibody detects endogenous levels of TRP12/TRPV4 protein.
Molecular Weight: 96kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: osm-9-like TRP channel 4; OTRPC 4; OTRPC4; Transient receptor potential cation channel subfamily V member 4; Transient receptor potential protein 12; TRP 12; TRP12; TRPV 4; Vanilloid receptor-like channel 2; Vanilloid receptor-like protein 2; Vanilloid receptor-related osmotically-activated channel; VR 4; VR OAC; VR4; VRL 2; VRL2; VROAC.
Immunogen: KLH conjugated synthetic peptide derived from human TRPV4:301-400/871
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: affinity purified by Protein A
Pathway:
