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Product Description
PAK4 monoclonal Antibody | MB64341 | Bioworld
Host: Mouse
Reactivity: Human, Mouse, Rat
Application: WB
Application Range: WB 1:2000
Background: PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Storage & Stability: PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Specificity: p21 (RAC1) activated kinase 4
Molecular Weight: 63.9 kDa (Predicted)
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: effector for Cdc42Hs; p21 protein (Cdc42; p21 (CDKN1A) -activated kinase 4; p21-activated kinase 4; protein kinase related to S. cerevisiae STE20; Rac) -activated kinase 4
Immunogen: Human recombinant protein fragment corresponding to amino acids 1-308 of human PAK4 (NP_005875) produced in E.coli.
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Pathway: N/A
