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Product Description
ACTR-IIA polyclonal Antibody | BS6967 | Bioworld
Host: Rabbit
Reactivity: Human,Mouse,Rat
Application: WB IHC IF
Application Range: WB: 1:500~1:2000 IHC: 1:50~1:200 IF: 1:50~1:200
Background: Members of the transforming growth factor β superfamily bind to a pair of transmembrane proteins, known as receptor types I and II, which contain serine/threonine kinases and associate to form a signaling complex. Activin has been shown to bind a heteromeric noncovalent complex, which consists of a type I receptor, ACTR-IA (also designated ACVRI and ALK-2) or ACTR-IB (also designated ALK-4 and SKR2), and a type II receptor, ACTR-IIA (ACVR2A) or ACTR-IIB (ACVR2B) . Both receptor types are highly expressed in brain. The activin receptor family members are thought to mediate distinct effects on gene expression, cell differentiation and morphogenesis in a dose dependent manner.
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: ACTR-IIA polyclonal Antibody detects endogenous levels of ACTR-IIA protein.
Molecular Weight: ~ 57 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: Activin receptor type-2A; EC=2.7.11.30; Activin receptor type IIA; ACTR-IIA; ACTRIIA; ACVR2A; ACVR2
Immunogen: Recombinant full length Human ACTR-IIA.
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Pathway:
