Euro
USD
British Pound
NULL
Product Description
CDC2 (Phospho-T161) polyclonal Antibody | BS64553 | Bioworld
Host: Rabbit
Reactivity: Human,Mouse,Rat
Application: WB IHC
Application Range: WB: 1:500~1:1000 IHC: 1:50~1:200
Background: Cdc2, an evolutionarily conserved serine/threonine-specific protein kinase, is essential in the cell cycle transition from G2 to M phase. Cdc2 is regulated by association with B-type cyclins and by reversible phosophorylation. Cyclin B binding facilitates the phosphorylation of Cdc2 p34 on three regulatory sites: threonine 14, tyrosine 15, and threonine 161. In higher eukaryotes, Cdc2 is negatively regulated by phosphorylation of two residues located in the ATP-binding site, Thr 14 and Tyr 15. Cdc2 is positively regulated by the cyclin-dependent phosphorylation of Thr 161. Both phosphorylation and de- phosphorylation at Thr 161 are required for progression through the cell cycle.
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: CDC2 (Phospho-T161) polyclonal Antibody detects endogenous levels of CDC2 protein only when phosphorylated at Thr161.
Molecular Weight: ~ 34 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: Cyclin-dependent kinase 1; Cell division control protein 2 homolog; Cell division protein kinase 1; p34 protein kinase; CDK1; CDC2; CDC28A; CDKN1; P34CDC2
Immunogen: Synthetic phosphopeptide derived from human CDC2 around the phosphorylation site of Threonine 161.
Conjugate: Unconjugated
Modification: Phosphorylation
Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Pathway:
![Phospho-CDC2 (T161) Antibody [APR05109G]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/500x659/products/866885/1158952/logo__92149.1659788186__69992.1659863411.png?c=2 "Phospho-CDC2 (T161) Antibody [APR05109G]"){kind=logo}