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Product Description
IBTK polyclonal Antibody | BS72498 | Bioworld
Host: Rabbit
Reactivity: Human
Application: WB
Application Range: WB 1:500 - 1:2000
Background: Bruton tyrosine kinase (BTK) is a protein tyrosine kinase that is expressed in B cells, macrophages, and neutrophils. The protein encoded by this gene binds to BTK and downregulates BTK's kinase activity. In addition, the encoded protein disrupts BTK-mediated calcium mobilization and negatively regulates the activation of nuclear factor-kappa-B-driven transcription. This gene has a pseudogene on chromosome 18. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: IBTK polyclonal Antibody detects endogenous levels of IBTK protein.
Molecular Weight: ~ 150 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: BTBD26;BTKI
Immunogen: Recombinant protein of human IBTK
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Pathway: Dopamine Signaling in Parkinson's Disease Plathway,Mitochondrial Control of Apoptosis,
