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Product Description
MDC1 polyclonal Antibody | BS71182 | Bioworld
Host: Rabbit
Reactivity: Human
Application: WB IHC IF
Application Range: WB 1:500 - 1:2000 IHC 1:100 - 1:200 IF 1:50 - 1:200
Background: The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci.
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: MDC1 polyclonal Antibody detects endogenous levels of MDC1 protein.
Molecular Weight: ~ 270 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: NFBD1;
Immunogen: Recombinant protein of human MDC1.
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Pathway:
