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Product Description
Raptor (phospho-Ser792) polyclonal Antibody | AP4001 | Bioworld
Host: Rabbit
Reactivity: Human,Mouse
Application: WB
Application Range: WB: 1:500~1:1000
Background: Regulatory associated protein of FRAP, also designated Raptor, is a binding partner for mammalian target of rapamycin kinase (FRAP), and is essential for FRAP signalling in vivo. Raptor binding to FRAP is critical for FRAP-catalysed substrate phosphorylation of 4E-BP1. The raptor-FRAP complex is nutrient-sensitive and is important for a mechanism by which cells coordinate cell growth and size with changing environmental conditions. Raptor serves as a negative regulator of FRAP kinase activity under nutrient-deprived conditions and is an important component in the FRAP pathway. Raptor is highly expressed in skeletal muscle and to a lesser extent in brain, kidney, lung and placenta.
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: A phospho specific peptide corresponding to residues surrounding Ser792 of human RPTOR
Molecular Weight: ~ 150 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: Regulatory-associated protein of mTOR; Raptor; p150 target of rapamycin (TOR) -scaffold protein; RPTOR; KIAA1303; RAPTOR
Immunogen: Synthetic phosphopeptide derived from human Raptor around the phosphorylation site of Ser792.
Conjugate: Unconjugated
Modification: Phosphorylation
Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Pathway: Hedgehog Signaling,
