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Product Description
UHRF1 polyclonal Antibody (ChIP Grade) | BS7227 | Bioworld
Host: Rabbit
Reactivity: Human
Application: WB IHC IF
Application Range: WB: 1:500~1:2000 IHC/IF: 1:50~1:200
Background: UHRF1, also named as ICBP90, NP95 and RNF106, is a putative E3 ubiquitin-protein ligase. It may participate in methylation-dependent transcriptional regulation. UHRF1 binds to inverted 5-CCAAT-3 box 2 in the TOP2A promoter, and activates TOP2A expression. It is important for G1/S transition and may be involved in DNA repair and chromosomal stability. UHRF1s ability to repress its direct target gene expression is dependent on PHD (UHRF1) binding to unmodified H3R2.
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: UHRF1 polyclonal Antibody detects endogenous levels of UHRF1 protein.
Molecular Weight: ~ 110 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: E3 ubiquitin-protein ligase UHRF1; Nuclear protein 95; Nuclear zinc finger protein Np95; HuNp95; hNp95; RING finger protein 106; Transcription factor ICBP90; hUHRF1; ICBP90; NP95; RNF106
Immunogen: Recombinant full length Human UHRF1.
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Pathway: Translational Contral elF4 and p70 S6 Kinase,
