Euro
USD
British Pound
NULL
Product Description
ABL1/2 (phospho-Y393/439) polyclonal Antibody | BS4727 | Bioworld
Host: Rabbit
Reactivity: Human,Mouse,Rat
Application: WB IHC IF
Application Range: WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200
Background: The Abl oncogene was initially identified as the viral transforming gene of Abelson murine leukemia virus (A-MuLV) . The major translational product of c-Abl has been identified as a protein with tyrosine kinase activity and an SH2 domain. The Abl oncogene is implicated in several human leukemias including 90-95% of chronic myelocytic leukemia (CML), 20-25% of adult acute lymphoblastic leukemia (ALL) and 2-5% of pediatric ALL. In these leukemias the c-Abl proto-oncogene undergoes a (9;22) chromosomal translocation producing the Philadelphia (Ph1) chromosome. The molecular consequence of this translocation is the generation of a chimeric Bcr/c-Abl mRNA encoding activated Abl protein-tyrosine kinase.
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: p-ABL1/2 (Y393/439) polyclonal Antibody detects endogenous levels of ABL1 protein only when phosphorylated at Tyr393 and ABL2 protein only when phosphorylated at Tyr439.
Molecular Weight: ~ 123 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: Tyrosine-protein kinase ABL1; Abelson murine leukemia viral oncogene homolog 1; Abelson tyrosine-protein kinase 1; Proto-oncogene c-Abl; p150; ABL1; ABL; JTK7; Abelson tyrosine-protein kinase 2; Abelson murine leukemia viral oncogene homolog 2; Abelson-related gene protein; Tyrosine-protein kinase ARG; ABL2; ABLL; ARG
Immunogen: Synthetic phosphopeptide derived from human ABL1/2 around the phosphorylation site of Tyrosine 393/439.
Conjugate: N/A
Modification: N/A
Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Pathway: N/A
![Phospho-ABL1 (Y393) /ABL2 (439) Antibody [APR05099G]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/500x659/products/866863/1158930/logo__92149.1659788186__66709.1659863402.png?c=2 "Phospho-ABL1 (Y393) /ABL2 (439) Antibody [APR05099G]"){kind=logo}
