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Product Description
Cytokeratin 18 (phospho-S33) polyclonal Antibody | BS4113 | Bioworld
Host: Rabbit
Reactivity: Human,Mouse,Rat
Application: WB IHC
Application Range: WB: 1:500~1:1000 IHC: 1:50~1:200
Background: Cytokeratin 18 encodes the type I intermediate filament chain keratin 18. Keratin 18, together with its filament partner keratin 8, are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene.Involved in the uptake of thrombin-antithrombin complexes by hepatic cells By similarity. When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6) -mediated barrier protection.
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: p-Cytokeratin 18 (S33) polyclonal Antibody detects endogenous levels of Cytokeratin 18 protein only when phosphorylated at Ser33.
Molecular Weight: ~ 46 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: Keratin, type I cytoskeletal 18; Cell proliferation-inducing gene 46 protein; Cytokeratin-18; Short name=CK-18; Keratin-18; Short name=K18; KRT18; CYK18; PIG46; KRT 18; CK 18; CK18; Keratin 18; Keratin18; CK-18
Immunogen: Synthetic phosphopeptide derived from human Cytokeratin 18 around the phosphorylation site of Serine 33.
Conjugate: Unconjugated
Modification: Phosphorylation
Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Pathway: Regulation of Actin Dynamics,Regulation of Microtubule Dynamics,
