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Product Description
GARS polyclonal Antibody | BS90561 | Bioworld
Host: Rabbit
Reactivity: Human, Mouse, Rat
Application: WB IHC
Application Range: WB:1:1,000-1:2,000 IHC:1:50-1:200
Background: The fidelity of protein synthesis requires efficient discrimination of amino acid substrates by aminoacyl-tRNA synthetases. Proteins belonging to this family function to catalyze the aminoacylation of tRNAs by their corresponding amino acids, thus linking amino acids with tRNA-contained nucleotide triplets. GlyRS (Glycyl-tRNA synthetase), also known as Glycine-tRNA ligase, is a 739 amino acid class II synthetase that is widely expressed, including in the brain and spinal cord. Defects in the gene encoding GlyRS is the cause of Charcot-Marie-Tooth disease type 2D (CMT2D), which is an autosomal dominant inherited disease characterized by severe weakness, atrophy and absence of deep tendon reflexes in the upper extremities. Defects in the GlyRS gene is also the cause of distal hereditary muscular neuropathy type V (HMN5), a disease similar to CMT2D, though the distal sensory involvement is less severe in HMN5 patients.
Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Specificity: GARS polyclonal Antibody detects endogenous levels of GARS protein.
Molecular Weight: 75 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: AP-4-A synthetase, GlyRS, GARS, AP 4 A synthetase, Charcot Marie Tooth neuropathy 2D, Charcot Marie Tooth neuropathy neuronal type D, CMT2D, Diadenosine tetraphosphate synthetase, DSMAV, EC 6.1.1.14, Glycine tRNA ligase, Glycyl tRNA synthetase, GlyRS, HMN5, SMAD1,
Immunogen: recombinant protein
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: ProA affinity purified
Pathway:
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