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Product Description
Laminin γ-1 (E1472) polyclonal Antibody | BS2416 | Bioworld
Host: Rabbit
Reactivity: Human,Mouse,Rat
Application: WB IHC IF
Application Range: WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200
Background: Laminins are essential and abundant structural non-collagenous glycoproteins localizing to basement membranes. Basement membranes (cell-associated extracellular matrices (ECMs) ) are polymers of Laminins with stabilizing Type IV Collagen networks, Nidogen and several proteoglycans. Basement membranes are found under epithelial layers, around the endothelium of blood vessels, and surrounding muscle, peripheral nerve and fat cells. Formation of basement membranes influences cell proliferation, phenotype, migration, gene expression and tissue architecture. Each Laminin is a heterotrimer of α, β and γ chain subunits that undergoes cell-secretion and incorporation into the ECM. Laminins can self-assemble, bind to other matrix macromolecules and have unique and shared cell interactions mediated by Integrins, dystroglycan and cognate Laminin receptors. The human Laminin γ-1 gene maps to chromosome 1q31 and is ubiquitously expressed in tissues that produce basement membranes.
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: Laminin γ-1 (E1472) pAb detects endogenous levels of Laminin γ-1 protein.
Molecular Weight: ~ 178 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: Laminin subunit gamma-1; Laminin B2 chain; Laminin-1 subunit gamma; S-laminin subunit gamma; S-LAM gamma; LAMC1; LAMB2
Immunogen: Synthetic peptide, corresponding to amino acids 1441-1490 of Human Laminin γ-1.
Conjugate: N/A
Modification: N/A
Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Pathway: N/A
