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Product Description
p53 (phospho-S392) Rabbit monoclonal Antibody | BS9894M | Bioworld
Host: Rabbit
Reactivity: Human,Mouse,Rat
Application: WB IHC
Application Range: WB: 1:1000-1:5000 IHC: 1:50-1:200
Background: p53, a DNA-binding, oligomerization domain and transcription activation domain-containing tumor suppressor, upregulates growth arrest and apoptosisrelated genes in response to stress signals, thereby influencing programmed cell death, cell differentiation and cell cycle control mechanisms. p53 localizes to the nucleus, yet can be chaperoned to the cytoplasm by the negative regulator MDM2, an E3 ubiquitin ligase that is upregulated in the presence of active p53, where MDM2 poly-ubiquitinates p53 for proteasome targeting. p53 fluctuates between latent and active (DNA-binding) conformations and is differentially activated through posttranslational modifications including phosphorylation and acetylation.
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: This Antibody detects endogenous levels of human p53 protein only when phosphorylated at Ser392.
Molecular Weight: ~ 53,43 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: Cellular tumor antigen p53; Antigen NY-CO-13; Phosphoprotein p53; Tumor suppressor p53; TP53; P53
Immunogen: Recombinant Antibody.
Conjugate: Unconjugated
Modification: Phosphorylation
Purification & Purity: Protein A affinity purified
Pathway:
