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Product Description
Tau (phospho-S396) polyclonal Antibody | BS4196 | Bioworld
Host: Rabbit
Reactivity: Human,Mouse,Rat
Application: WB IHC
Application Range: WB: 1:500~1:1000 IHC: 1:50~1:200
Background: Tau, also known as MAPT (microtubule-associated protein tau), MAPTL, MTBT1 or TAU, is a 758 amino acid protein that localizes to the cytoplasm, as well as to the cytoskeleton and the cell membrane, and contains four Tau/MAP repeats. Expressed in neuronal tissue and existing as multiple alternatively spliced isoforms, Tau functions to promote microtubule assembly and stability and is thought to be involved in the maintenance of neuronal polarity. Tau may also link microtubules with neural plasma membrane components and, addition to its role in microtubule stability, is also necessary for cytoskeletal plasticity.
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: p-Tau (S396) polyclonal Antibody detects endogenous levels of Tau only when phosphorylated at Ser713, isoforms Tau-4 phosphorylated at Ser396, and other isoforms phosphorylated at the corresponding Site.
Molecular Weight: 50 to 80 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: Microtubule-associated protein tau; Neurofibrillary tangle protein; Paired helical filament-tau; PHF-tau; MAPT; MAPTL; MTBT1; TAU
Immunogen: Synthetic phosphopeptide derived from human isoforms Tau-4 around the phosphorylation site of Serine 396.
Conjugate: Unconjugated
Modification: Phosphorylation
Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Pathway: Neuronal and Glial Cell Marker Atlas,Amyloid Plaque and Neurofibrillary Tangle Formation in Alzheimer's Disease,
