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Product Description
TGase2/TGM2 polyclonal Antibody | BS91335 | Bioworld
Host: Rabbit
Reactivity: Human, Mouse
Application: WB IHC IP
Application Range: WB:1:500-1:2,000 IHC:1:50-1:200
Background: Terminally differentiating mammalian epidermal cells acquire an insoluble, 10 to 20 nm thick protein deposit on the intracellular surface of the plasma membrane known as the cross-linked cell envelope (CE) . The CE is a component of the epidermis that is generated through formation of disulfide bonds and g-glutamyl-lysine isodipeptide bonds, which are formed by the action of transglutaminases (TGases) . TGases are intercellularly localizing, Ca2+-dependent enzymes that catalyze the formation of isopeptide bonds by transferring an amine on to glutaminyl residues, thereby cross-linking glutamine residues and lysine residues in substrate proteins. TGases influence numerous biological processes, including blood coagulation, epidermal differentiation, seminal fluid coagulation, fertilization, cell differentiation and apoptosis. Human keratinocyte transglutaminase (TGase1) is a membrane associated, 817 amino acid protein. Human tissue transglutaminase (TGase2) is an endothelial cell specific, 687 amino acid protein.
Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Specificity: TGase2/TGM2 polyclonal Antibody detects endogenous levels of TGase2/TGM2 protein.
Molecular Weight: 77 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: TG (C), TGC, TGase C, TGase H, TGase-2, TGM2, ALPHA SUBUNIT, C polypeptide, EC 2.3.2.13 Antibodyepididymis secretory protein Li 45, G alpha h, G[a]h, Gh CLASS G ALPHA h, GNAH, GNAH G PROTEIN, H POLYPEPTIDE, HEL-S-45, Protein glutamine gamma glutamyltransferase 2, Protein-glutamine gamma-glutamyltransferase 2, TG 2, TG (C), TG2, TGase C, TGase H, TGase-2, TgaseII, TGC, TGC GUANINE NUCLEOTIDE BINDING PROTEIN, TGM2, TGM2, Tissue transglutaminase, Transglutaminase 2, Transglutaminase 2 C polypeptide, Transglutaminase C, Transglutaminase H, Transglutaminase-2, tTG, tTGas,
Immunogen: Recombinant protein
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: ProA affinity purified
Pathway: TGFβ Smad signaling,
