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Product Description
WIP (Y455) polyclonal Antibody | BS9169 | Bioworld
Host: Rabbit
Reactivity: Human,Mouse,Rat
Application: WB IHC
Application Range: WB: 1:500~1:1000 IHC: 1:50~1:200
Background: Mutations in the Wiskott-Aldrich syndrome protein (WASP) often result in immunodeficiency due to abnormal T cell and B cell activation. The 503 amino acid WAS-interacting protein (WIP) contains a number of domains implicated in Actin-binding and several putative SRC homology-binding domains. The first 100 amino acids of WASP interact with amino acids 377-503 of WIP, and the majority of pathogenic mutations associated with WAS occur within the first 100 amino acids of WASP. The gene encoding human WIP maps to chromosome 2q31.1. Overexpression of WIP in the human B cell line BJAB increases F-Actin content and cerebriform projections. While both WIP and Vav cooperate in the regulation of NF-AT/AP-1 gene transcription, the WIP-WASP complex is required for activation of NF-AT/AP-1 necessary for proper T cell function. A dysfunctional WIP-WASP complex may be implicated in the immunodeficient phenotype in WAS.
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: WIP (Y455) polyclonal Antibody detects endogenous levels of WIP protein.
Molecular Weight: ~51 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: WAS/WASL-interacting protein family member 1; Protein PRPL-2; Wiskott-Aldrich syndrome protein-interacting protein; WASP-interacting protein; WIPF1; WASPIP; WIP
Immunogen: Synthetic peptide, corresponding to amino acids 431-480 of Human WIP.
Conjugate: N/A
Modification: N/A
Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Pathway: N/A
